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Synthesis 2023; 55(04): 657-662
DOI: 10.1055/a-1941-1437
DOI: 10.1055/a-1941-1437
paper
Convenient Synthesis of Ellagic Acid from Methyl Gallate and SARS-CoV-2 3CLpro Antiviral Activity
Financial support from Servier Laboratories is gratefully acknowledged.
Abstract
A practical synthesis of ellagic acid has been achieved from methyl gallate by a proposed synthetic route of five steps, consisting of ketal protection, regioselective bromination, bis-lactonization, C–C bond formation between the aromatic rings of the galloyl groups, and ketal deprotection, in 38% overall yield. Ellagic acid showed a slight inhibitory activity against SARS-CoV-2 3CLpro.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1941-1437.
- Supporting Information
Publication History
Received: 28 July 2022
Accepted after revision: 12 September 2022
Accepted Manuscript online:
12 September 2022
Article published online:
18 October 2022
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