Effect Produced by a Cyclooctyne Derivative on Both Infarct Area and
                    Left Ventricular Pressure via Calcium Channel Activation

Figueroa-Valverde Lauro; Rosas-Nexticapa Marcela; López-Ramos Maria; Díaz-Cedillo Francisco; Alvarez-Ramirez Magdalena; Mateu-Armad Maria Virginia; Melgarejo-Gutierrez Montserrat

doi:10.1055/a-1967-2004

Drug Research, Table of Contents

Drug Res (Stuttg) 2023; 73(02): 105-112
DOI: 10.1055/a-1967-2004

Original Article

Effect Produced by a Cyclooctyne Derivative on Both Infarct Area and Left Ventricular Pressure via Calcium Channel Activation

Figueroa-Valverde Lauro

¹Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. Campeche, Camp., México.

,

Rosas-Nexticapa Marcela

²Facultad de Nutrición, Universidad Veracruzana, Médicos y Odontologos s/n C.P. Unidad del Bosque Xalapa Veracruz, México.

,

López-Ramos Maria

¹Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Agustín Melgar s/n, Col Buenavista C.P. Campeche, Camp., México.

,

Díaz-Cedillo Francisco

³Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P.

,

Alvarez-Ramirez Magdalena

³Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P.

,

Mateu-Armad Maria Virginia

³Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P.

,

Melgarejo-Gutierrez Montserrat

⁴Facultad de Medicine, Universidad Veracruzana, Médicos y Odontologos s/n C.P. Unidad del Bosque Xalapa Veracruz, México

› Author Affiliations

Abstract

Background There are reports which indicate that some cyclooctyne derivatives may exert changes in cardiovascular system; however, its molecular mechanism is not very clear.

Objective The aim of this study was to evaluate the biological activity of four cyclooctyne derivatives (compounds 1 to 4) produced on infarct area and left ventricular pressure.

Methods Biological activity produced by cyclooctyne derivatives on infarct area was determinate using an ischemia/reperfusion injury model. In addition, to characterize the molecular mechanism of this effect, the following strategies were carried out as follows; i) biological activity produced by cyclooctyne derivative (compound 4) on either perfusion pressure or left ventricular pressure was evaluated using an isolated rat heart; ii) theoretical interaction of cyclooctyne derivative with calcium channel (1t0j protein surface) using a docking model.

Results The results showed that cyclooctyne derivative (compound 4) decrease infarct area of in a dose-dependent manner compared with compound 1 to 3. Besides, this cyclooctyne derivative increase both perfusion pressure and left ventricular pressure which was inhibited by nifedipine. Other theoretical data suggests that cyclooctyne derivative could interact with some aminoacid residues (Met₈₃, Ile₈₅, Ser₈₆, Leu₁₀₈, Glu₁₁₄) involved in 1t0j protein surface.

Conclusions All these data indicate that cyclooctyne derivative increase left ventricular pressure via calcium channel activation and this phenomenon could be translated as a decrease of infarct area.

Key words

Cyclooctyne - derivative - infarct - ischemia - calcium channel.

Full Text

References

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