Abstract
Chemical reactivity plays a major role in understanding several aspects of selectivity. Therefore, in this account, we present a plethora of reactions that demonstrate our efforts in exploiting interesting cases of selectivity over the past three decades. Among them, chemoselectivity, regioselectivity and stereoselectivity are discussed. Strain, steric factors, and separation of the reacting functionalities are revealed as prominent features in generating selectivity.
1 Introduction
2 Chemoselectivity
3 Regioselectivity
4 Diastereoselectivity
5 Substrate-Based Selectivity
6 Reagent-Based Selectivity
7 Steric-Volume-Induced Selectivity
8 Role of Temperature and Reaction Time in Achieving Selectivity
9 Role of the Catalyst in Observing Selectivity
10 Separation as a Parameter for Selectivity
11 pK
a (Acidity of the Active Methylene Component)
12 Sequence as a Tool for Selectivity
13 Strain of the Ring System
14 Examples of Miscellaneous Selectivity
15 Conclusions
Key words
metathesis - cycloaddition - Grignard reaction - Fischer indolization - Diels–Alder reaction - cyclophane - quinane
