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Planta Med 2023; 89(07): 729-734
DOI: 10.1055/a-1997-5692
Biological and Pharmacological Activity
Original Papers

New Ionone Glycosides from the Aerial Parts of Allium sativum and Their Anti-Platelet Aggregation Activity

Bin Hu
1   National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, China
3   Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China
,
Haibo Hu
1   National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, China
,
Chuan Pu
1   National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, China
,
Donghui Peng
3   Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China
,
Zheng Wei
3   Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China
4   Ganzhou peopleʼs Hospital, Ganzhou, China
,
Haixue Kuang
3   Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China
,
Qiuhong Wang
2   College of TCM, Guangdong Pharmaceutical University, Guangzhou, China
› Author AffiliationsSupported by: Starting Fund for Scientific Research of High-level Talents of Gannan Medical University QD202009
Supported by: Chinese Medicine Science and Technology Plan Project of Jiangxi Province 2020A0357
Supported by: Key special project of “Research on modernization of traditional Chinese medicine” in national key R & D plan of China 2018YFC1707100
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Abstract

The bulbs of Allium sativum known as garlic are widely used as food or seasoning. In China they have been used as a traditional Chinese medicine (TCM) since ancient times for the treatment of scabies, tuberculosis, pertussis, diarrhea and dysentery. A. sativum has reportedly shown platelet aggregation inhibition and has been used in the treatment of cardiovascular diseases. However, there are only few studies focussing on the aerial parts, which are normally discarded during harvest. In this study, two new ionone glycosides, dasuanxinosides D and E (1, 2), are isolated from the aerial parts together with 13 known compounds including alkanes derivatives and alkyl glycosides (3 – 15), which are reported for the first time from this plant. Their structures are identified by extensive NMR and HRMS analyses. The isolated compounds are evaluated for their inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro.

Key words

Allium sativum - Amaryllidaceae - ionone glycosides - alkyl glycosides - platelet aggregation

Supporting Information

    The NMR, HR-ESI-MS, UV and IR spectra of compounds 1 and 2 are available as Supporting Information.

  • Supporting Information


Publication History

Received: 12 August 2022

Accepted after revision: 09 December 2022

Accepted Manuscript online:
13 December 2022

Article published online:
23 February 2023

© 2023. Thieme. All rights reserved.

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