Synthesis 2023; 55(09): 1460-1466
Ruthenium-Catalyzed Regioselective Synthesis of C3-Alkylated Indoles Following Transfer Hydrogenation or Borrowing Hydrogen Strategy
Xia Chen
a
School of Chemistry and Materials Engineering, Liupanshui Normal University, Liupanshui 553004, P. R. of China
b
Guizhou Key Laboratory of Coal Clean Utilization, Liupanshui 553004, P. R. of China
,
Xiao-Yu Zhou∗
a
School of Chemistry and Materials Engineering, Liupanshui Normal University, Liupanshui 553004, P. R. of China
b
Guizhou Key Laboratory of Coal Clean Utilization, Liupanshui 553004, P. R. of China
› Author Affiliations The authors are grateful to National Natural Science Foundation of China (Nos. 22062012 and 22262019) and Scientific Research Projects of Liupanshui Normal University (LPSSYZDZK202201) for their financial support. This work was also supported by Guizhou Key Laboratory of Coal Clean Utilization (qiankehepingtairencai [2020]2001).
Abstract
By employing either borrowing hydrogen or transfer hydrogenation strategy, two straightforward [Ru(p -cymene)Cl2 ]2 -catalyzed methods for regioselective synthesis of C3-alkylated indoles have been developed, utilizing alcohols as H atom donors or alkylating agents. The developed catalytic system could accommodate a broad substrate scope including primary/secondary aliphatic alcohols and substituted indoles, and in most cases providing good yields. Notable features of the developed system include high-activity, easy operation, and air atmosphere.
Key words
transfer hydrogenation -
borrowing hydrogen -
alkylation -
indoles -
alcohols
Supporting Information
Supporting information for this article is available online at https://doi.org/10.1055/a-2003-3207.
Supporting Information
Publication History
Received: 01 December 2022
© 2022. Thieme. All rights reserved
Georg Thieme Verlag KG
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