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Synthesis 2023; 55(18): 2985-2992
DOI: 10.1055/a-2038-9146
DOI: 10.1055/a-2038-9146
paper
Special Issue Electrochemical Organic Synthesis
Electrosynthesis of Flavanones via oxa-Michael Addition Using Sacrificial Electrodes
The authors would like to thank the FAPESP (grant numbers: 2022/00074-3 (G. M. M.), and 2021/13924-2 (P. P. C.), FAPESC (grant number: 2021TR964), Capes (001) and INCT-Catálise-FAPESC.
Abstract
An electrochemical synthesis of flavanones via oxa-Michael addition using silver electrode as a sacrifice is reported. This electrosynthetic system showed good yields, broad substrate scope, and good functional group tolerance. Additionally, the method proved to be applicable on a gram-scale. Several studies were carried out to elucidate the reaction mechanism, such as control reactions, cyclic voltammetry, and theoretical studies, allowing the proposal of a plausible pathway for this transformation.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2038-9146.
- Supporting Information
Publication History
Received: 13 December 2022
Accepted after revision: 20 February 2023
Accepted Manuscript online:
20 February 2023
Article published online:
22 March 2023
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