Abstract
Purpose To determine the effect of fasting plasma glucose (FPG) level at
admission affects the 90-day mortality rate in patients with viral
pneumonia.
Methods Two hundred fifty viral pneumonia patients were stratified into
normal FPG (FPG<7.0 mmol/L), moderately-elevated FPG
(FPG=7.0–14.0 mmol/L), and highly-elevated FPG
groups (FPG≥14.0 mmol/L) according to the FPG level at
the time of admission. The clinical characteristics, etiologies, and prognosis
of different groups of patients were compared. Kaplan-Meier survival and Cox
regression analyses were used to determine the relationship between the FPG
level and 90-day all-cause mortality rate in patients with viral pneumonia.
Results Patients in the moderately- and highly-elevated FPG groups had a
higher proportion of severe disease and mortality compared with the normal FPG
group (P<0.001). Kaplan-Meier survival analysis showed a significant
trend toward higher mortality and increased cumulative risk at 30, 60, and 90 d
in patients with an FPG=7.0–14.0 mmol/L and an
FPG≥14 mmol/L (χ2=51. 77,
P<0.001). Multivariate Cox regression analysis revealed that compared
with an FPG<7.0 mmol/L, FPG=7.0 and
14.0 mmol/L (HR: 9.236, 95% CI: 1.106–77.119,
P=0.040) and FPG≥14.0 mmol/L (HR: 25.935,
95% CI: 2.586–246.213, P=0.005) were independent risk
factors for predicting the 90-day mortality rate in viral pneumonia
patients.
Conclusions The higher the FPG level at admission in a patient with viral
pneumonia, the higher the risk of all-cause mortality within 90 d.
Key words
viral pneumonia - fasting plasma glucose level - type 2 diabetes - survival analysis
