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Int J Sports Med 2023; 44(09): 634-641
DOI: 10.1055/a-2053-7613
Physiology & Biochemistry

Peripheral Arterial Stiffness is Associated with Maximal Oxygen Uptake in Athletes

Yuto Hashimoto 
1   Research Institute for Sports Science, Nippon Sport Science University, Setagaya-ku, Japan
,
Takanobu Okamoto
2   Department of exercise physiology, Nippon Sport Science University, Setagaya-ku, Japan
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Abstract

Increased central arterial stiffness is associated with decreased maximal oxygen uptake (V̇O2max). Endurance exercise training improves arterial function throughout the whole body, but the relationship between central and peripheral arterial stiffness and V̇O2max is unknown. The present study investigated the relationship between central and peripheral arterial stiffness and V̇O2max in endurance-trained athletes. Twenty-one young male endurance-trained athletes and 12 sedentary controls were included in this study. Resting values for carotid-femoral velocity and femoral-ankle pulse wave velocity were obtained to assess central and peripheral arterial stiffness, respectively. V̇O2max was obtained by incremental cycle ergometer testing. Both carotid-femoral pulse wave velocity (P=0.019) and femoral-ankle pulse wave velocity (P=0.028) were lower in athletes than in controls. V̇O2max was significantly higher in athletes compared to controls (P<0.001). Significant correlations were found between carotid-femoral pulse wave velocity and V̇O2max (r=–0.510, P=0.018) and between femoral-ankle pulse wave velocity and V̇O2max (r=–0.472, P=0.031) in athletes. However, no correlations were evident in controls. These results suggest that higher V̇O2max is associated with lower peripheral arterial stiffness in addition to central arterial stiffness among endurance-trained athletes.

Key words

pulse wave velocity - central artery - peripheral artery - maximal oxygen uptake - endurance - athlete performance


Publication History

Received: 02 August 2022

Accepted: 21 February 2023

Article published online:
30 May 2023

© 2023. Thieme. All rights reserved.

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  • References

  • 1 Plowman SA, Smith DL. Exercise Physiology: For Health, Fitness, and Performance. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2014
    Search in Google Scholar
  • 2 Billat VL, Demarle A, Slawinski J. et al. Physical and training characteristics of top-class marathon runners. Med Sci Sports Exerc 2001; 33: 2089-2097
    CrossrefPubMedSearch in Google Scholar
  • 3 Lundby C, Montero D, Joyner MJ. Biology of VO2max: looking under the physiology lamp. Acta Physiol (Oxf) 2017; 220: 218-228
    CrossrefPubMedSearch in Google Scholar
  • 4 Tomoto T, Maeda S, Sugawara J. Relation between arterial stiffness and aerobic capacity: Importance of proximal aortic stiffness. Eur J Sport Sci 2017; 17: 571-575
    CrossrefPubMedSearch in Google Scholar
  • 5 Boreham CA, Ferreira I, Twisk JW. et al. Cardiorespiratory fitness, physical activity, and arterial stiffness: The Northern Ireland young hearts project. Hypertension 2004; 44: 721-726
    CrossrefPubMedSearch in Google Scholar
  • 6 Namgoong H, Lee D, Hwang MH. et al. The relationship between arterial stiffness and maximal oxygen consumption in healthy young adults. J Exerc Sci Fit 2018; 16: 73-77
    CrossrefPubMedSearch in Google Scholar
  • 7 Ashor AW, Lara J, Siervo M. et al. Effects of exercise modalities on arterial stiffness and wave reflection: A systematic review and meta-analysis of randomized controlled trials. PLoS One 2014; 9: e110034
    CrossrefPubMedSearch in Google Scholar
  • 8 Hashimoto Y, Okamoto T. Arterial stiffness and left ventricular diastolic function in endurance athletes. Int J Sports Med 2021; 42: 497-505
    PubMedSearch in Google Scholar
  • 9 Snell PG, Martin WH, Buckey JC. et al. Maximal vascular leg conductance in trained and untrained men. J Appl Physiol (1985) 1987; 62: 606-610
    CrossrefPubMedSearch in Google Scholar
  • 10 Boushel R, Langberg H, Green S. et al. Blood flow and oxygenation in peritendinous tissue and calf muscle during dynamic exercise in humans. J Physiol 2000; 524: 305-313
    CrossrefPubMedSearch in Google Scholar
  • 11 Hammer SM, Hammond ST, Parr SK. et al. Influence of muscular contraction on vascular conductance during exercise above versus below critical power. Respir Physiol Neurobiol 2021; 293: 103718
    CrossrefPubMedSearch in Google Scholar
  • 12 Saltin B, Calbet JAL, Wagner PD. Point: In health and in a normoxic environment, V̇O2max is limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol (1985) 2006; 100: 744-748
    CrossrefPubMedSearch in Google Scholar
  • 13 Ridout SJ, Parker BA, Smithmyer SL. et al. Age and sex influence the balance between maximal cardiac output and peripheral vascular reserve. J Appl Physiol (1985) 2010; 108: 483-489
    CrossrefPubMedSearch in Google Scholar
  • 14 Christiansen D, Eibye K, Hostrup M. et al. Training with blood flow restriction increases femoral artery diameter and thigh oxygen delivery during knee-extensor exercise in recreationally trained men. J Physiol 2020; 598: 2337-2353
    CrossrefPubMedSearch in Google Scholar
  • 15 Fernberg U, Fernström M, Hurtig-Wennlöf A. Arterial stiffness is associated to cardiorespiratory fitness and body mass index in young Swedish adults: The Lifestyle, Biomarkers, and Atherosclerosis study. Eur J Prev Cardiol 2017; 24: 1809-1818
    CrossrefPubMedSearch in Google Scholar
  • 16 Otsuki T, Maeda S, Iemitsu M. et al. Relationship between arterial stiffness and athletic training programs in young adult men. Am J Hypertens 2007; 20: 967-973
    CrossrefPubMedSearch in Google Scholar
  • 17 Sugawara J, Hayashi K, Yokoi T. et al. Brachial–ankle pulse wave velocity: An index of central arterial stiffness?. J Hum Hypertens 2005; 19: 401-406
    CrossrefPubMedSearch in Google Scholar
  • 18 Harriss DJ, Jones C, MacSween A. Ethical standards in sport and exercise science research: 2022 update. Int J Sports Med 2022; 43: 1065-1070
    Thieme ConnectPubMedSearch in Google Scholar
  • 19 Kobayashi R, Yoshida S, Okamoto T. Arterial stiffness after glucose ingestion in exercise-trained versus untrained men. Appl Physiol Nutr Metab 2015; 40: 1151-1156
    CrossrefPubMedSearch in Google Scholar
  • 20 Williams B, Mancia G, Spiering W. et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J 2018: 3021-3104
    PubMed
  • 21 Willemet M, Chowienczyk P, Alastruey J. A database of virtual healthy subjects to assess the accuracy of foot-to-foot pulse wave velocities for estimation of aortic stiffness. Am J Physiol Heart Circ Physiol 2015; 309: H663-H675
    CrossrefPubMedSearch in Google Scholar
  • 22 Yamato Y, Hasegawa N, Sato K. et al. Acute effect of static stretching exercise on arterial stiffness in healthy young adults. Am J Phys Med Rehabil 2016; 95: 764-770
    CrossrefPubMedSearch in Google Scholar
  • 23 Charry D, Gouskova N, Meyer ML. et al. Arterial stiffness and contralateral differences in blood pressure: The Atherosclerosis Risk in Communities (ARIC) study. J Clin Hypertens 2022; 24: 878-884
    CrossrefPubMedSearch in Google Scholar
  • 24 The jamovi project. jamovi. (Version 1.6). 2021
    PubMed
  • 25 R Core Team. R: A Language and environment for statistical computing. (Version 4.0). 2020
    PubMed
  • 26 Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, New Jersey: Lawrence Erlbaum Associates; 1988
    Search in Google Scholar
  • 27 Kerby DS. The simple difference formula: An approach to teaching nonparametric correlation. Compr Psychol 2014; 3: 1-9
    CrossrefPubMedSearch in Google Scholar
  • 28 Mäki-petäjä KM, Barrett SML, Evans SV. et al. The role of the autonomic nervous system in the regulation of aortic stiffness. Hypertension 2016; 68: 1290-1297
    CrossrefPubMedSearch in Google Scholar
  • 29 Ferreira I, Twisk JWR, Stehouwer CDA. et al. Longitudinal changes in V̇ O2max: Associations with carotid IMT and arterial stiffness. Med Sci Sports Exerc 2003; 35: 1670-1678
    CrossrefPubMedSearch in Google Scholar
  • 30 Florescu M, Stoicescu C, Magda S. et al. “Supranormal” cardiac function in athletes related to better arterial and endothelial function. Echocardiography 2010; 27: 659-667
    CrossrefPubMedSearch in Google Scholar
  • 31 Matsuda M, Nosaka T, Sato M. et al. Effects of physical exercise on the elasticity and elastic components of the rat aorta. Eur J Appl Physiol Occup Physiol 1993; 66: 122-126
    CrossrefPubMedSearch in Google Scholar
  • 32 Maeda S, Miyauchi T, Kakiyama T. et al. Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans. Life Sci 2001; 69: 1005-1016
    CrossrefPubMedSearch in Google Scholar
  • 33 Bourque SL, Davidge ST, Adams MA. The interaction between endothelin-1 and nitric oxide in the vasculature: New perspectives. Am J Physiol Regul Integr Comp Physiol 2011; 300: R1288-R1295
    CrossrefPubMedSearch in Google Scholar
  • 34 Cook JN, DeVan AE, Schleifer JL. et al. Arterial compliance of rowers: Implications for combined aerobic and strength training on arterial elasticity. Am J Physiol Heart Circ Physiol 2006; 290: H1596-H1600
    CrossrefPubMedSearch in Google Scholar
  • 35 Palmieri V, Palmieri EA, Arezzi E. et al. Peak exercise oxygen uptake and left ventricular systolic and diastolic function and arterial mechanics in healthy young men. Eur J Appl Physiol 2004; 91: 664-668
    CrossrefPubMedSearch in Google Scholar
  • 36 Steding K, Engblom H, Buhre T. et al. Relation between cardiac dimensions and peak oxygen uptake. J Cardiovasc Magn Reson 2010; 12: 8
    CrossrefPubMedSearch in Google Scholar
  • 37 Kolh P, D’Orio V, Lambermont B. et al. Increased aortic compliance maintains left ventricular performance at lower energetic cost. Eur J Cardiothorac Surg 2000; 17: 272-278
    CrossrefPubMedSearch in Google Scholar
  • 38 Tomoto T, Sugawara J, Hirasawa A. et al. Impact of short-term training camp on arterial stiffness in endurance runners. J Physiol Sci 2015; 65: 445-449
    CrossrefPubMedSearch in Google Scholar
  • 39 Coates AM, Millar PJ, Burr JF. Blunted cardiac output from overtraining is related to increased arterial stiffness. Med Sci Sports Exerc 2018; 50: 2459-2464
    PubMedSearch in Google Scholar
  • 40 Shibata S, Fujimoto N, Hastings JL. et al. The effect of lifelong exercise frequency on arterial stiffness. J Physiol 2018; 596: 2783-2795
    CrossrefPubMedSearch in Google Scholar
  • 41 Van De Laar RJ, Ferreira I, Van Mechelen W. et al. Habitual physical activity and peripheral arterial compliance in young adults: The Amsterdam growth and health longitudinal study. Am J Hypertens 2011; 24: 200-208
    CrossrefPubMedSearch in Google Scholar
  • 42 Karabulut M, Esparza B, Dowllah IM. et al. The impact of low-intensity blood flow restriction endurance training on aerobic capacity, hemodynamics, and arterial stiffness. J Sports Med Phys Fitness 2021; 61: 877-884
    CrossrefPubMedSearch in Google Scholar
  • 43 Rakobowchuk M, Tanguay S, Burgomaster KA. et al. Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans. Am J Physiol Regul Integr Comp Physiol 2008; 295: R236-R242
    CrossrefPubMedSearch in Google Scholar
  • 44 Rud B, Foss O, Krustrup P. et al. One-legged endurance training: Leg blood flow and oxygen extraction during cycling exercise. Acta Physiol (Oxf) 2012; 205: 177-185
    CrossrefPubMedSearch in Google Scholar
  • 45 Dinenno FA, Tanaka H, Monahan KD. et al. Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. J Physiol 2001; 534: 287-295
    CrossrefPubMedSearch in Google Scholar
  • 46 Beck DT, Martin JS, Casey DP. et al. Exercise training reduces peripheral arterial stiffness and myocardial oxygen demand in young prehypertensive subjects. Am J Hypertens 2013; 26: 1093-1102
    CrossrefPubMedSearch in Google Scholar
  • 47 Hambrecht R, Gielen S, Linke A. et al. Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure: A randomized trial. JAMA 2000; 283: 3095-3101
    CrossrefPubMedSearch in Google Scholar
  • 48 Okamoto T, Kobayashi R, Hashimoto Y. et al. Is individual day-to-day variation of arterial stiffness associated with variation of maximal aerobic performance?. BMC Sports Sci Med Rehabil 2021; 13: 4
    CrossrefPubMedSearch in Google Scholar
  • 49 Tanaka H, Dinenno FA, Monahan KD. et al. Aging, habitual exercise, and dynamic arterial compliance. Circulation 2000; 102: 1270-1275
    CrossrefPubMedSearch in Google Scholar
  • 50 Gledhill N, Cox D, Jamnik R. Endurance athletes’ stroke volume does not plateau: major advantage is diastolic function. Med Sci Sports Exerc 1994; 26: 1116-1121
    CrossrefPubMedSearch in Google Scholar
  • 51 Coates AM, Millar PJ, Burr JF. Blunted cardiac output from overtraining is related to increased arterial stiffness. Med Sci Sports Exerc 2018; 50: 2459-2464
    CrossrefPubMedSearch in Google Scholar
  • 52 Belz GG. Elastic properties and Windkessel function of the human aorta. Cardiovasc Drugs Ther 1995; 9: 73-83
    CrossrefPubMedSearch in Google Scholar
  • 53 Salerni S, Di Francescomarino S, Cadeddu C. et al. The different role of sex hormones on female cardiovascular physiology and function: Not only oestrogens. Eur J Clin Invest 2015; 45: 634-645
    CrossrefPubMedSearch in Google Scholar
  • 54 Diaz-Canestro C, Montero D. The impact of sex on left ventricular cardiac adaptations to endurance training: A systematic review and meta-analysis. Sports Med 2020; 50: 1501-1513
    Search in Google Scholar
  • 55 Vlachopoulos C, Kardara D, Anastasakis A. et al. Arterial stiffness and wave reflections in marathon runners. Am J Hypertens 2010; 23: 974-979
    Search in Google Scholar
  • 56 Burr JF, Drury CT, Phillips AA. et al. Long-term ultra-marathon running and arterial compliance. J Sci Med Sport 2014; 17: 322-325
    CrossrefPubMedSearch in Google Scholar