Bilateral Anotia In A Preterm Neonate After Maternal Retinoic Acid Exposure

Introduction

Isotretinoin (also termed 13-cis retinoic acid) is a synthetic vitamin A derivative often prescribed to treat severe acne, but is one of the most potent human teratogens. Retinoids including 13-cis retinoic acid are physiologically present in blood at low concentrations, also in pregnant women [Czuba CL et al., Nutrients 2022; 14: 1365]. Both vitamin A deficiency and excess during pregnancy can trigger birth defects and intrauterine death [Maia SB et al., Nutrients 2019; 11:681]. Isotretinoin is contraindicated for women who are or may become pregnant. We here present the case of a preterm newborn with multiple anomalies whose mother had taken isotretinoin during pregnancy.

Publication History

Article published online:
28 July 2023