Palladium-Catalyzed Asymmetric 1,4-Addition of Diarylphosphines to α,β-Unsaturated Sulfonyl Fluorides

Dedicated to Professor Guoqiang Lin on the occasion of his 80^th birthday

Abstract

A Pd-catalyzed asymmetric phosphination of α,β-unsaturated sulfonyl fluorides was developed, and a series of tertiary phosphorus compounds were obtained in excellent yields and enantioselectivities (up to 99% ee). The chiral adduct can be further converted into chiral phosphine sulfonic acid as the ligand for the arene Ru metal complex.

Key words

α,β-unsaturated sulfonyl fluoride - asymmetric 1,4-addition - palladium catalyst - chiral phosphine

Publication History

Received: 28 February 2023

Accepted after revision: 03 April 2023

Accepted Manuscript online:
03 April 2023

Article published online:
22 May 2023

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