Synlett 2023; 34(17): 1939-1942
DOI: 10.1055/a-2080-5631
synpacts

A Sulfoxide Reagent for Sulfinylative Cross-Coupling

Fumito Saito
This work was supported by the Walter Benjamin Program (500656103) of the Deutsche Forschungsgemeinschaft.


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Abstract

I recently documented the strategic use of a sulfoxide reagent as a sulfur monoxide equivalent to enable one-pot, three-component syntheses of sulfoxides and sulfinamides. The sulfoxide reagent donates the SO unit upon the reaction with Grignard reagents (RMgX) as sulfenate anions (RSO). The anionic sulfur intermediates can be readily transformed into sulfoxides and sulfinamides via trapping with appropriate carbon and nitrogen electrophiles. This Synpacts article highlights my first efforts to establish a general sulfinylative cross-coupling platform.

1 Introduction

2 Development of a Sulfoxide Reagent as a Sulfur Monoxide Equivalent

3 Conclusions and Future Directions



Publication History

Received: 09 April 2023

Accepted after revision: 25 April 2023

Accepted Manuscript online:
25 April 2023

Article published online:
25 May 2023

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