Synlett 2024; 35(01): 109-112
DOI: 10.1055/a-2109-0055
cluster
Functional Dyes

Dual Responses of Fluorescence and Circular Dichroism for Antibiotics by a Cationic Cage in Water

Yunhong Dong‡
a   Xi’an Key Laboratory of Functional Supramolecular Structure and Materials, College of Chemistry and Materials Science, Northwest University, Xi’an 710069, P. R. of China
,
Lin Cheng∗
a   Xi’an Key Laboratory of Functional Supramolecular Structure and Materials, College of Chemistry and Materials Science, Northwest University, Xi’an 710069, P. R. of China
,
Yanjuan Duan
a   Xi’an Key Laboratory of Functional Supramolecular Structure and Materials, College of Chemistry and Materials Science, Northwest University, Xi’an 710069, P. R. of China
,
Huiru Xu
b   State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P. R. of China
,
Ruonan Dong
b   State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P. R. of China
,
Baolin Guo
b   State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P. R. of China
,
Liping Cao∗
a   Xi’an Key Laboratory of Functional Supramolecular Structure and Materials, College of Chemistry and Materials Science, Northwest University, Xi’an 710069, P. R. of China
› Author AffiliationsThis work was supported by the National Natural Science Foundation of China (22122108 and 21971208), the Natural Science Basic Research Plan for Distinguished Young Scholars in Shaanxi Province of China (2021JC-37), and the Fok Ying Tong Education Foundation (171010). L.C. thanks Xi’an Key Laboratory of Functional Supramolecular Structure and Materials (CFZKFKT23001) and the Shaanxi Fundamental Science Research Project for Chemistry and Biology (22JHQ073).
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Abstract

A tetraphenylethene (TPE)-based cationic cage (1) can form a 1:2 host–guest complex with antibiotics in water and imparts dual responses of fluorescence and circular dichroism (CD) to antibiotics based on the fluorescence and adaptive chiral conformation of the TPE units. Moreover, the host–guest complexes 1⊃(antibiotic)2 exhibited good antibacterial activity.

Key words

chiral response - host–guest recognition - tetraphenylethene-based cationic cage - antibiotics - antibacterial activity

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2109-0055.
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Publication History

Received: 04 May 2023

Accepted after revision: 12 June 2023

Accepted Manuscript online:
12 June 2023

Article published online:
03 August 2023

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