Kinder- und Jugendmedizin 2023; 23(05): 291-303
DOI: 10.1055/a-2112-6882
Schwerpunkt

Woran denken bei Gelenkschmerzen?

Painfull joints – what might be the reason?
Johannes-Peter Haas
1   Deutsches Zentrum für Kinder und Jugendrheumatologie, Kinderklinik gGmbH, Garmisch-Partenkirchen, Ludwig-Maximillians Universität, München
› Author Affiliations

ZUSAMMENFASSUNG

Gelenksbeschwerden und Schmerzen im Bereich des muskulo-skelettalen Systems gehören zu den häufigsten Symptomen in kinder- und jugendmedizinischen Praxen und Ambulanzen. Meistens handelt es sich um temporäre durch Bagatelltraumen und/oder Überlastung verursachte Beschwerden oder eine Begleitreaktion z. B. im Rahmen von Infektionserkrankungen. Wiederholte und/oder länger anhaltende Beschwerden insbesondere in gleicher Lokalisation bedürfen jedoch einer eingehenden Abklärung. Differenzialdiagnostisch ist bei unklaren Gelenksbeschwerden eine Vielzahl von Erkrankungen möglich, die zum Teil sehr selten auftreten. Dies erschwert die zielorientierte Abklärung für den Praktiker. Eine rechtzeitige Diagnostik kann einerseits das Auftreten bleibender Schäden und andererseits bedrohliche Verkäufe, die bei einigen Erkrankungen die das muskulo-skelettale System betreffen möglich sind, vermeiden helfen. Die folgende Zusammenstellung soll hier einen praxisorientierten Leitfaden bieten.

ABSTRACT

Painful joints and limbs are one of the most frequent symptoms in child- and adulthood. The majority of cases will suffer temporarily from pain resulting from trauma and/or overstressing. Moreover muscular-skeletal symptoms may accompany infectious diseases. Repeating or long lasting pain at the same location respectively requires more precise investigations. As the diagnostic routine has to consider a lot of different and some very rare diseases a goal-orientated work-up is sometimes difficult. Early diagnosis is mandatory to prevent from potential permanent damage as well as to hinder threatening courses which might develop in some diseases to be considered. The following review provides a guideline for the practitioner.



Publication History

Article published online:
16 October 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG,
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Roth-Isigkeit A, Raspe HH, Stoven H. et al Pain in children and adolescents – -results of an exploratory epidemiological study]. Schmerz 2003; 17: 171-178
  • 2 Todd KH, Ducharme J, Choiniere M. et al Pain in the emergency department: results of the pain and emergency medicine initiative (PEMI) multicenter study. The journal of pain: official journal of the American Pain Society 2007; 08: 460-466
  • 3 Birnbaum K, Stollbrink-Peschgens C, Hübner D, Niethard FU. Diagnostischer Algorithmus zum Ausschluss des „Wachstumsschmerzes“. Monatsschr Kinderheilkd 2000; 148: 876-882
  • 4 Haas JP.. Entzündliche Knochen- und Gelenkserkrankungen. In: Reinhardt D (Hrsg). Therapie der Krankheiten im Kindes- und Jugendalter. 9. Aufl. Berlin, New York: Springer; 2013
  • 5 Townes JM, Deodhar AA, Laine ES. et al Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study. Annals of the rheumatic diseases 2008; 67: 1689-1696
  • 6 Bratton RL, Whiteside JW, Hovan MJ. et al Diagnosis and treatment of Lyme disease. Mayo Clinic proceedings Mayo Clinic 2008; 83: 566-571
  • 7 Haas JP. Genetic background of juvenile idiopathic arthritis. Zeitschrift für Rheumatologie 2010; 69: 488-495
  • 8 Häfner R, Haas JP. Genetische Arthropathien und Skelettdysplasien: Differenzialdiagnosen bei schmerzhaften und kontrakten Gelenken (Genetic Arthropathy and Skeletal Dysplasia: Differential Diagnosis in Painful and Contracted Joints). Akt Rheumatol 2016; 41: 396-406
  • 9 Jones OY, Spencer CH, Bowyer SL. et al A multicenter case-control study on predictive factors distinguishing childhood leukemia from juvenile rheumatoid arthritis. Pediatrics 2006; 117: e840-844
  • 10 Resnik CS. Diagnostic imaging of pediatric skeletal trauma. Radiologic clinics of North America 1989; 27: 1013-1022
  • 11 Hofel L, Draheim N, Schramm A. et al Rheumatic pain and chronic pain in children, adolescents and young adults. Z Rheumatol 2021; 80 (03) 234-242
  • 12 Barata I, Spencer R, Suppiah A. et al Emergency ultrasound in the detection of pediatric long-bone fractures. Pediatric emergency care 2012; 28: 1154-1157
  • 13 Bickerstaff DR, Neal LM, Brennan PO. et al An investigation into the etiology of irritable hip. Clinical pediatrics 1991; 30: 353-356
  • 14 Collado P, Vojinovic J, Nieto JC. et al Toward Standardized Musculoskeletal Ultrasound in Pediatric Rheumatology: Normal Age-Related Ultrasound Findings. Arthritis Care Res (Hoboken) 2016; 68: 348-356
  • 15 El-Miedany YM, Housny IH, Mansour HM. et al Ultrasound versus MRI in the evaluation of juvenile idiopathic arthritis of the knee. Joint, bone, spine: revue du rhumatisme 2001; 68: 222-230
  • 16 Gohar F, Windschall D. The new role of musculoskeletal ultrasound in the treat-to-target management of juvenile idiopathic arthritis. Rheumatology (Oxford) 2021; 60 (05) 2046-2053
  • 17 Trauzeddel R, Lehman H, Trauzeddel RF. et al Age dependent ultrasound B-mode findings of the elbow joint in healthy children and adolescents. Rheumatol Int 2019; 39: 1007-1018
  • 18 Trauzeddel R, Windschall D, Trauzeddel RF. et al Arthrosonographic Reference Values of the Shoulder Joint in Healthy Children and Adolescents: A Cross-Sectional Multicentre Ultrasound Study. Klin Padiatr 2017; 229: 293-301
  • 19 Trauzeddel RF, Lehmann H, Windschall D. et al Age-dependent arthrosonographic reference values of the hip joint in healthy children and adolescents – a cross-sectional multicenter ultrasound study. Pediatr Radiol 2017; 47: 1329-1336
  • 20 Windschall D, Malattia C. Ultrasound imaging in paediatric rheumatology. Best Pract Res Clin Rheumatol 2020; 34: 101570
  • 21 Alanay Y, Lachman RS. A review of the principles of radiological assessment of skeletal dysplasias. Journal of clinical research in pediatric endocrinology 2011; 03: 163-178
  • 22 Uhl M, Geiger J, Strohm PC. Skeletal trauma during the growing period. Radiological diagnostics. Der Radiologe 2011; 51: 719-734 quiz 735–716
  • 23 Jans LB, Ditchfield M, Anna G. et al MR imaging findings and MR criteria for instability in osteochondritis dissecans of the elbow in children. European journal of radiology 2012; 81: 1306-1310
  • 24 Pagnini I, Savelli S, Matucci-Cerinic M. et al Early predictors of juvenile sacroiliitis in enthesitis-related arthritis. The Journal of rheumatology 2010; 37: 2395-2401
  • 25 Yercan HS, Okcu G, Erkan S. Synovial hemangiohamartomas of the knee joint. Arch Orthop Trauma Surg 2007; 127: 281-285
  • 26 Kaste SC. PET-CT in children: where is it appropriate?. Pediatric radiology 2011; 41 (Suppl. 02) 509-513
  • 27 Wananukul S, Voramethkul W, Kaewopas Y. et al Prevalence of positive antinuclear antibodies in healthy children. Asian Pacific journal of allergy and immunology/launched by the Allergy and Immunology Society of Thailand 2005; 23: 153-157
  • 28 Breda L, Nozzi M, De Sanctis S. et al Laboratory tests in the diagnosis and follow-up of pediatric rheumatic diseases: an update. Seminars in arthritis and rheumatism 2010; 40: 53-72
  • 29 Sethi S, Kaushik K, Mohandas K. et al Anti-streptolysin O titers in normal healthy children of 5–15 years. Indian pediatrics 2003; 40: 1068-1071
  • 30 Höfel L, Jonietz AL, Schnöbel-Müller E. et al Chronische Schmerzstörung mit somatischen und psychischen Faktoren bei Kindern und Jugendlichen. Pädiatrische Praxis 2018; 90: 258-268
  • 31 Hafner R, Truckenbrodt H, Spamer M. Rehabilitation in children with juvenile chronic arthritis. Baillieres Clin Rheumatol 1998; 12: 329-361
  • 32 Bunikis J, Barbour AG. Laboratory testing for suspected Lyme disease. The Medical clinics of North America 2002; 86: 311-340
  • 33 Jeske M, Lohse P, Kallinich T. et al Genotype-phenotype and genotype-origin correlations in children with mediterranean fever in Germany – an AID-net study. Klinische Padiatrie 2013; 225: 325-330
  • 34 Schanberg LE, Anthony KK, Gil KM. et al Daily pain and symptoms in children with polyarticular arthritis. Arthritis and rheumatism 2003; 48: 1390-1397
  • 35 Haas JP, Arbogast M. Therapeutic options in juvenile idiopathic arthritis: Part 1: Nonsurgical treatment. Der Orthopade 2018; 47 (11) 912-918
  • 36 Oommen PT, Schütz K, Baltruschat K. et al S2k-Leitlinie „Therapie der Juvenilen Idiopathischen Arthritis“. In. www.awmf.org/leitlinien/aktuelle-leitlinien.html AWMF 2019
  • 37 Ellert U, Neuhauser H, Roth-Isigkeit A. Pain in children and adolescents in Germany: the prevalence and usage of medical services. Results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2007; 50: 711-717
  • 38 Huguet A, Eccleston C, Miro J. et al Young people making sense of pain: cognitive appraisal, function, and pain in 8–16 year old children. Eur J Pain 2009; 13: 751-759
  • 39 O’Sullivan P, Beales D, Jensen L. et al Characteristics of chronic non-specific musculoskeletal pain in children and adolescents attending a rheumatology outpatients clinic: a cross-sectional study. Pediatr Rheumatol Online J 2011; 09: 3
  • 40 Nilges P, Rief W. F45.41 Chronische Schmerzstörung mit somatischen und psychischen Faktoren. Schmerz 2010; 24: 209-212
  • 41 Draheim N, Ebinger F, Schnoebel-Mueller E. et al Definition, Diagnostik und Therapie von chronischen Schmerzen in mehreren Körperregionen und des (sog.) Fibromyalgiesyndroms bei Kindern und Jugendlichen: aktualisierte Leitlinie 2017 [Definition, diagnostics and therapy of chronic widespread pain and the (so-called) fibromyalgia syndrome in children and adolescents: Updated guidelines 2017]. Schmerz 2017; 31: 296-307
  • 42 Yunus MB, Masi AT. Juvenile primary fibromyalgia syndrome. A clinical study of thirty-three patiens and matched normal controls. Arthritis & rheumatology 1985; 28: 138-145
  • 43 Haas JP. Vaskulitiden des Kindes- und Jugendalters. Pädiatrische Praxis 2022; 98: 1-19
  • 44 Oommen PT, Strauss T, Baltruschat K. et al Update of evidence- and consensus-based guidelines for the treatment of juvenile idiopathic arthritis (JIA) by the German Society of Pediatric and Juvenile Rheumatic Diseases (GKJR): New perspectives on interdisciplinary care. Clin Immunol 2022; 245: 109143
  • 45 Haas JP, Arbogast M. Therapeutic options in juvenile idiopathic arthritis: Surgical and conservative orthopedic rheumatological treatment. Z Rheumatol 2021; 80 (05) 467-480
  • 46 Arbogast M, Haas JP. Treatment options in juvenile idiopathic arthritis: Part 2: Orthopedics und surgery. Der Orthopade 2018; 47 (11) 919-927
  • 47 Hinze CH, Holzinger D, Lainka E. et al Practice and consensus-based strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany. Pediatr Rheumatol Online J 2018; 16: 7
  • 48 Hinze CH, Oommen PT, Dressler F. et al Development of practice and consensus-based strategies including a treat-to-target approach for the management of moderate and severe juvenile dermatomyositis in Germany and Austria. Pediatr Rheumatol Online J 2018; 16: 40
  • 49 Spamer M, Georgi M, Hafner R. et al Physiotherapy for juvenile idiopathic arthritis. Zeitschrift fur Rheumatologie 2012; 71: 387-395
  • 50 Bunner E-M, Flessa S, Häfner R. et al Kinderrheumatologische Komplexbehandlung – Teil 2: Soziale und pädagogische Therapie. Orthopädie und Rheuma 2010; 04: 56-64
  • 51 Bouiller K, David MZ. Staphylococcus aureus Genomic Analysis and Outcomes in Patients with Bone and Joint Infections: A Systematic Review. Int J Mol Sci 2023; 24 (04) 3234
  • 52 Umer M, Hashmi P, Ahmad T. et al Septic arthritis of the hip in children – Aga Khan University Hospital experience in Pakistan. JPMA The Journal of the Pakistan Medical Association 2003; 53: 472-478
  • 53 Li CW, Ma JJ, Yin J. et al Reiter’s syndrome in children: a clinical analysis of 22 cases. Zhonghua er ke za zhi Chinese journal of pediatrics 2010; 48: 212-215
  • 54 Wisniewska-Ligier M, Wozniakowska-Gesicka T, Sobanska A. et al Extrapulmonary complications of Mycoplasma pneumoniae infections. Przeglad lekarski 2003; 60: 832-835
  • 55 Nimmrich S, Becker I, Horneff G. Intraarticular corticosteroids in refractory childhood Lyme arthritis. Rheumatol Int 2014; 34: 987-994
  • 56 Moon MS, Kim SS, Lee SR. et al Tuberculosis of hip in children: A retrospective analysis. Indian journal of orthopaedics 2012; 46: 191-199
  • 57 De Laere E, Berghs B, Gordts B. et al Primary meningococcal arthritis of the hip in an immunocompetent adolescent. Acta clinica Belgica 2002; 57: 345-348
  • 58 de Groot R, Glover D, Clausen C. et al Bone and joint infections caused by Kingella kingae: six cases and review of the literature. Reviews of infectious diseases 1988; 10: 998-1004
  • 59 Mignemi ME, Martus JE, Bracikowski AC. et al The spectrum of group A streptococcal joint pathology in the acute care setting. Pediatric emergency care 2012; 28: 1185-1189
  • 60 Rasmont Q, Yombi JC, Van der Linden D. et al Osteoarticular infections in Belgian children: a survey of clinical, biological, radiological and microbiological data. Acta orthopaedica Belgica 2008; 74: 374-385
  • 61 Takei M, Kitamura N, Nagasawa Y. et al Are Viral Infections Key Inducers of Autoimmune Diseases? Focus on Epstein-Barr Virus. Viruses 2022; 14 (09) 1900
  • 62 Jackson LC. Malaria in Liberian children and mothers: biocultural perceptions of illness vs clinical evidence of disease. Social science & medicine 1985; 20: 1281-1287
  • 63 Brunner J, Sitzmann FC. The diagnostic value of anti-cyclic citrullinated peptide (CCP) antibodies in children with Juvenile Idiopathic Arthritis. Clinical and experimental rheumatology 2006; 24: 449-451