Synthesis, Inhaltsverzeichnis Synthesis 2023; 55(21): 3610-3616DOI: 10.1055/a-2114-5426 special topic C–H Bond Functionalization of Heterocycles Sustainable Ru(II)-Catalyzed ortho-C(sp2)–H Hydroxyalkylation of Phthalazinones Using Ethyl Glyoxalate: Access to α,α′-Arylcarboxy sec-Alcohols Alagumalai Ramkumar , Thirumanavelan Gandhi∗ Artikel empfehlen Abstract Artikel einzeln kaufen Alle Artikel dieser Rubrik Abstract An operationally simple and expeditious protocol for Ru(II)-catalyzed ortho-C(sp2)–H hydroxyalkylation of phthalazinones using commercially available ethyl glyoxalate in 2-Me-THF is reported. This greener approach involves the imine nitrogen on the phthalazinones as a directing group to effect the regioselective hydroxyalkylation. Ample examples of biologically relevant hydroxyalkylated phthalazinones were prepared, and relevant controlled studies were performed to decipher the reaction mechanism. 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