Nephrologie aktuell 2023; 27(10): 471-477
DOI: 10.1055/a-2128-2355
Schwerpunkt
Dialyse

Ernährungstherapie bei Dialysepflicht

Fokus auf die intradialytische parenterale Ernährung (IDPE)
Tobias A. Marsen
1   Kuratorium für Dialyse und Nierentransplantation, Nierenzentrum Köln-Lindenthal, Köln
› Author Affiliations

ZUSAMMENFASSUNG

Bislang konnte nicht nachgewiesen werden, dass intradialytische parenterale Ernährung (IDPE) im Vergleich zu einer Ernährungsberatung und einer oralen Nahrungsergänzung bei terminaler Niereninsuffizienz die Patientengesundheit oder klinisch wichtige Ernährungsergebnisse verbessert. Aufgrund der Verbesserung von Ernährungsindikatoren empfehlen jedoch die bestehenden Leitlinien die IDPE als sinnvolle weitere Behandlungsoption für Patienten, die auf eine Ernährungsberatung und eine orale Nahrungsergänzung nicht ansprechen oder diese Erstbehandlungen aufgrund einer Fehlfunktion des Magen-Darm-Trakts oder anderer Probleme nicht erhalten können. Trotz der höheren Kosten ist somit ein Einsatz der IDPE gerechtfertigt. Zu den Nebenwirkungen der IDPE liegen nur begrenzt Daten vor. Es scheint jedoch keine signifikanten Unterschiede bezüglich unerwünschter Wirkungen zwischen Therapie- und Kontrollgruppe zu geben. In der klinischen Praxis sollte die IDPE immer auch gegen die anderen Ernährungsoptionen abgewogen und individuell über einen idealerweise initial zu definierenden und klar limitierten Zeitraum verordnet werden.



Publication History

Article published online:
18 December 2023

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  • Literatur

  • 1 Kopple JD. Protein-energy-malnutrition in maintenance dialysis patients. Am J Clin Nutr 1997; 65: 1544-1557 DOI: 10.1093/ajcn/65.5.1544.
  • 2 Araujo IC, Kamimura MA, Draibe SA. et al Nutritional parameters and mortality in incident hemodialysis patients. J Ren Nutr 2006; 16: 27-35 DOI: 10.1053/j.jrn.2005.10.003.
  • 3 Fouque D, Kalantar-Zadeh K, Kopple J. et al A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 2008; 73: 391-398 DOI: 10.1038/sj.ki.5002585.
  • 4 Fukasawa H, Kaneko M, Niwa H. et al Lower thighmuscle mass is associated with all-cause and cardiovascular mortality in elderly hemodialysis patients. Eur J Clin Nutr 2017; 71: 64-69 DOI: 10.1038/ejcn.2016.186.
  • 5 Lemos T, Gallagher D. Current body composition measurement techniques. Curr Opin Endocrinol Diabetes Obes. 2017; 24: 310-314 DOI: 10.1097/MED.0000000000000360.
  • 6 Agarwal R, Georgianos P. Feeding during dialysis – risks and uncertainties. Nephrol Dial Transplant 2018; 33: 917-922 DOI: 10.1093/ndt/gfx195.
  • 7 Chan W. Chronic kidney disease and nutrition support. Nutr Clin Pract 2021; 36: 312-330 DOI: 10.1002/ncp.10658..
  • 8 Rocco MV, Dwyer JT, Larive B. et al The effects of dialysis does and membrane flux on nutrtional parameters in hemodialysis patient: results of the HEMO Study. Kidney Int 2004; 65: 2321-2334 DOI: 10.1111/j.1523-1755.2004.00647.x.
  • 9 Locatelli F, Martin-Malo A, Hannedouche T. et al Membrane Permeability Outcome (MPO) study group. Effects on membrane permeability on survival of hemodialysis patients. J Am Soc Nephrol 2009; 20: 645-654 DOI: 10.1681/ASN.2008060590.
  • 10 Linday RM, Nesrallah G, Suri R. et al Is more frequent hemodialysis beneficial and what is the evidence?. Curr Opin Nephro Hypertens 2004; 17: 24-25 DOI: 10.1097/00041552-200411000-00008.
  • 11 Kaysen GA, Greene T, Larive B. et al The effect of frequent hemodialysis on nutrition and body composition: Frequent Hemodialysis Network Trial. Kidney Int 2012; 82: 90-99 DOI: 10.1038/ki.2012.75.
  • 12 Lindsay RM, Spanner E, Heidenheim RP. et al Which comes first, Kt/V or PCR – chicken or egg?. Kidney Int Suppl 1992; 38: S32-S36
  • 13 Sezer S, Bal Z, Tutal E. et al Long-term oral nutrition supplementation improves outcomes in malnourished patients with chronic kidney disease on hemodialysis. JPEN J Parenter Enteral Nutr 2014; 38: 960-965 DOI: 10.1177/0148607113517266.
  • 14 Hiroshige K, Sonta T, Suda T. et al Oral supplementation of branched-chain amino acid improves nutritional status in elderly patients on chronic haemodialysis. Nephrol Dial Transplant 2001; 16: 1856-1862 DOI: 10.1093/ndt/16.9.1856.
  • 15 Fouque D, McKenzie J, de Mutsert R. et al Use of a renal-specific oral supplement by haemodialysis patients with low protein intake does not increase the need for phosphate binders and may prevent a decline in nutritional status and quality of life. Nephrol Dial Transplant 2008; 23: 2902-2910 DOI: 10.1093/ndt/gfn131.
  • 16 Calegari A, Barros EG, Veronese FV. et al Malnourished patients on hemodialysis improve after receiving a nutritional intervention. J Bras Nefrol 2011; 33: 394-401
  • 17 Wilson B, Fernandez-Madrid A, Hayes A. et al Comparison of the effects of two early intervention strategies on the health outcomes of malnourished hemodialysis patients. J Ren Nutr 2001; 11: 166-171 DOI: 10.1053/jren.2001.24364.
  • 18 Zakar G. Hungarian Ketosteril Cohort Study. The effect of a keto acid supplement on the course of chronic renal failure and nutritional parameters in predialysis patients and patients on regular hemodialysis therapy: The Hungarian Ketosteril Cohort Study. Wien Klin Wochenschr 2001; 113: 688-694
  • 19 Stratton RJ, Bircher G, Fouque D. et al Multinutrient oral supplements and tube feeding in maintenance dialysis: a systematic review and meta-analysis. Am J Kidney Dis 2005; 46: 387-405 DOI: 10.1053/j.ajkd.2005.04.036.
  • 20 Liu PJ, Ma F, Wang QY. et al The effects of oral nutritional supplements in patients with maintenance dialysis therapy: A systematic review and meta-analysis of randomized clinical trials. PLoS One 2018; 13: e0203706 DOI: 10.1371/journal.pone.0203706.
  • 21 Gharib MS, Nazeih MS, El Said TW. Effect of intradialytic oral nutritional supplementation on nutritional markers in malnourished chronic hemodialysis patients: prospective randomized trial. BMC Nephrol 2023; 24: 125 DOI: 10.1186/s12882-023-03181-7.
  • 22 Chertow GM, Ling J, Lew NL. et al The association of intradialytic parenteral nutrition administration with survival in hemodialysis patients. Am J Kidney Dis 1994; 24: 912-920 DOI: 10.1016/s0272-6386(12)81060-2.
  • 23 Capelli JP, Kushner H, Camiscioli TC. et al Effect of intradialytic parenteral nutrition on mortality rates in end-stage renal disease care. Am J Kidney Dis 1994; 23: 808-816 DOI: 10.1016/s0272-6386(12)80134-x.
  • 24 Avery-Lynch M. Intradialytic parenteral nutrition in hemodialysis patients: Acute and chronic intervention. CANNT J 2006; 16: 30-33
  • 25 Bilbrey G. Is intradialytic parenteral nutrition of benefit in hemodialysis patients?. Semin Dialysis 1993; 06: 168-170
  • 26 Bilbrey G, Cohen T. Identification and treatment of protein calorie malnutrition in chronic hemodialysis patients. Dial Transplant 1989; 18: 669-700
  • 27 Cherry N, Shalansky K. Efficacy of intradialytic parenteral nutrition in malnourished hemodialysis patients. Am J Health Syst Pharm 2002; 59: 1736-1741 DOI: 10.1093/ajhp/59.18.1736.
  • 28 Czekalski S, Hozejowski R. Intradialytic amino acids supplementation in hemodialysis patients with malnutrition: Results of a multicenter cohort study. J Ren Nutr 2004; 14: 82-88 DOI: 10.1053/j.jrn.2004.01.007.
  • 29 Korzets A, Azoulay O, Ori Y. et al The use of intradialytic parenteral nutrition in acutely ill haemodialysed patients. J Ren Care 2008; 34: 14-18 DOI: 10.1111/j.1755-6686.2008.00005.x.
  • 30 Madigan KM, Olshan A, Yingling DJ. Effectiveness of intradialytic parenteral nutrition in diabetic patients with end-stage renal disease. J Am Diet Assoc 1990; 90: 861-863
  • 31 Mortelmans AK, Duym P, Vandenbroucke J. et al Intradialytic parenteral nutrition in malnourished hemodialysis patients: A prospective long-term study. JPEN J Parenter Enteral Nutr 1999; 23: 90-95 DOI: 10.1177/014860719902300290.
  • 32 Noè D, Lanzi P, Spiti R. et al Effects of intradialytic parenteral nutrition on the nutritional status of malnourished uremic patients. Nutr Ther Metabol 2013; 31: 176-181
  • 33 Olshan A, Bruce J, Schwartz A. Intradialytic parenteral-nutrition administration during outpatient hemodialysis. Dial Transplant 1987; 16: 495-496
  • 34 Powers DV, Jackson A, Piraino AJ. Prolonged intradialysis hyperalimentation in chronic hemodialysis patients with an amino acid solution (renamin amino acid injection) formulated for renal failure. In: Kinney JM. Perspectives in clinical nutrition. Baltimore: Urban & Schwarzenberg 1989: 191-205
  • 35 Schulman G, Wingard RL, Hutchison RL. et al The effects of recombinant human growth hormone and intradialytic parenteral nutrition in malnourished hemodialysis patients. Am J Kidney Dis 1993; 21: 527-534 DOI: 10.1016/s0272-6386(12)80399-4.
  • 36 Siskind MS, Lien YH. Effect of intradialytic parenteral nutrition on quality of life in hemodialysis patients. Int J Artif Organs 1993; 16: 599-603
  • 37 Smolle KH, Kaufmann P, Holzer H. et al Intradialytic parenteral nutrition in malnourished patients on chronic haemodialysis therapy. Nephrol Dial Transplant 1995; 10: 1411-1416
  • 38 Snyder S, Bergen C, Sigler MH. et al Intradialytic parenteral nutrition in chronic hemodialysis patients. ASAIO Trans 1991; 37: M373-M375
  • 39 Szklarek-Kubicka M, Fijalkowska-Morawska J, Zaremba-Drobnik D. Effect of intradialytic intravenous administration of omega-3 fatty acids on nutritional status and inflammatory response in hemodialysis patients: A pilot study. J Ren Nutr 2009; 19: 487-493 DOI: 10.1053/j.jrn.2009.05.007.
  • 40 Thunberg B, Jain VK, Patterson PG. et al Nutritional measurementsand urea kinetics to guide intradialytic hyperalimentation. Proc Clin Dial Transplant Forum 1980; 10: 22-28
  • 41 Dezfuli A, Scholl D, Lindenfeld SM. et al Severity of hypoalbuminemia predictsresponse to intradialytic parenteral nutrition in hemodialysis patients. J Ren Nutr 2009; 19: 291-297 DOI: 10.1053/j.jrn.2009.01.023.
  • 42 Foulks CJ. The effect of intradialytic parenteral nutrition on hospitalization rate andmortality in malnourished hemodialysis patients. J Ren Nutr 1994; 04: 5-10
  • 43 Berneis K, Iseli-Schaub J, Garbani E. et al Effects of intradialytic parenteral nutrition in chronic haemodialysis patients with malnutrition: A pilot study. Wien Klin Wochenschr 1999; 111: 876-881
  • 44 Marsen TA, Beer J, Mann H. Intradialytic parenteral nutrition in maintenance hemodialysis patients suffering from protein-energy wasting. Results of a multicenter, open, prospective, randomized trial. Clin Nutr 2017; 36: 107-117 DOI: 10.1016/j.clnu.2015.11.016.
  • 45 Cano NJ, Fouque D, Roth H. et al Intradialytic parenteral nutrition does not improve survival in malnourished hemodialysis patients: A 2-year multicenter, prospective, randomized study. J Am Soc Nephrol 2007; 18: 2583-2591 DOI: 10.1681/ASN.2007020184.
  • 46 Kittiskulnam P, Banjongjit A, Metta K. et al The beneficial effects of intradialytic parenteral nutrition in hemodialysis patients with protein energy wasting: a prospective randomized controlled trial. Sci Rep 2022; 12: 4529 DOI: 10.1038/s41598-022-08726-8.
  • 47 Liu Y, Xiao X, Qin DP. et al Comparison of intradialytic parenteral nutrition with glucose or amino acid mixtures in maintenance hemodialysis patients. Nutrients 2016; 08: 220 DOI: 10.3390/nu8060220.
  • 48 Oğuz Y, Bulucu F, Vural A. Oral and parenteral essential amino acid therapy in malnourished hemodialysis patients. Nephron 2001; 89: 224-227 DOI: 10.1159/000046072.
  • 49 Cederholm T, Bosaeus I, Barazzoni R. et al Diagnostic criteria for malnutrition – an ESPEN consensus statement. Clin Nutr 2015; 34: 335-340 DOI: 10.1016/j.clnu.2015.03.001.
  • 50 Kalantar-Zadeh K, Kilpatrick RD, Kuwae N. et al Revisiting mortality predictability of serum albumin in the dialysis population: Time dependency, longitudinal changes and population-attributable fraction. Nephrol Dial Transpl 2005; 20: 1880-1888 DOI: 10.1093/ndt/gfh941.
  • 51 Pupim LB, Flakoll PJ, Brouillete JR. et al Intradialytic parenteral nutrition improves protein and energy homeostasis in chronic hemodialysis patients. J Clin Invest 2002; 110: 483-492 DOI: 10.1172/JCI15449..
  • 52 Pupim LB, Flakoll PJ, Ikizler TA. Nutritional supplementation acutely increases albumin fractional synthetic rate in chronic hemodialysis patients. J Am Sec Nephrol 2004; 15: 1920-1926 DOI: 10.1097/01.asn.0000128969.86268.c0.
  • 53 Ikizler A, Burrowes JD, Byham-Gray LD. et al KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update. Am J Kidney Dis 2020; 76: S1-S107 DOI: 10.1053/j.ajkd.2020.05.006.
  • 54 Demirci BG, Carrero JJ, Tutal E. et al Effect of nutritional support on nutritional status and inflammation in malnourished patients undergoing maintenance hemodialysis. Hemodial Int 2021; 25: 532-540 DOI: 10.1111/hdi.12936.