Abstract
Objective The aim of this study was to explore the effect of different organ metastasis on
the prognosis of non-small cell lung cancer (NSCLC).
Methods Patients with distant metastatic NSCLC were selected from Surveillance, Epidemiology,
and End Results database during 2016 to 2019. The incidence of different organ metastasis
and their association with clinicopathological factors were explored. Overall survival
(OS) and lung cancer-specific survival (LCSS) for metastatic NSCLC were calculated,
and multivariate Cox regression analysis was performed with a nomogram for OS being
constructed based on Cox regression.
Results Total 26,210 patients with distant metastatic NSCLC were included in this study.
Around 48.9% of the metastatic NSCLC were multiple-organ metastasis and bone was the
most commonly involved organ (44.4%). For patients with single-organ metastasis, the
prognosis for lung or distant lymph nodes (LNs) metastasis was better than others
(with median OS of 15 and 16 months for lung and distant LNs metastasis, respectively),
and liver metastasis resulted in the worst prognosis with median OS of 8 months. A
nomogram was constructed to visualize Cox regression model, along with the receiver
operating characteristic (ROC) curve demonstrated good discrimination for the predictive
model with 1- and 2-year area under the curve of ROC of 0.687 and 0.702, respectively.
Conclusion The prognosis of NSCLC patients with distant metastasis was poor. Liver metastasis
results in the worst prognosis among the single-organ metastasis. The nomogram developed
based on the Cox regression model has provided a useful tool to estimate the probability
of OS of the metastatic NSCLC.
Keywords
lung cancer - treatment - metastases - lung cancer - diagnosis
