Molekular zielgerichtete Therapien – brauchen wir überhaupt noch Chemotherapie?

Fortschritte im Verständnis der Biologie maligner Lymphome haben die Entwicklung zahlreicher molekular zielgerichteter Therapien ermöglicht. So kann die chronische lymphatische Leukämie heutzutage fast vollständig chemotherapiefrei behandelt werden. Doch wie sieht diese Entwicklung bei anderen Lymphomen aus? Im vorliegenden Artikel wollen wir eine Übersicht über molekular zielgerichtete Therapieansätze bei malignen B- und T-Zell-Lymphomen geben.

Abstract

Advances in the understanding of the biology of malignant lymphoma has facilitated the development of numerous molecularly targeted therapies. The incorporation of these precision therapeutics has produced more effective and often less-toxic treatment regimens leading to a significant improvement of treatment outcomes for individuals with lymphoid malignancies.

In relapsed diseases, molecularly targeted therapeutic approaches have demonstrated superior outcomes compared to conventional chemotherapy, leading to a growing number of patients being treated entirely chemotherapy-free. This review outlines the current landscape of targeted therapies for both B-cell (B-NHL) and T-cell non-Hodgkin lymphomas (T-NHL) and provides an overview of targeted agents currently approved for the treatment of malignant lymphoma.

Schlüsselwörter

Therapie - zielgerichtet - Lymphome - Non-Hodgkin-Lymphom - Hodgkin-Lymphome

Keywords

therapy - targeted - lymphoma - Non-Hodgkin-lymphoma - Hodgkin-lymphoma

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