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Thromb Haemost 2024; 124(03): 277-279
DOI: 10.1055/a-2174-0844
Letters to the Editor

Platelet Aggregation Is Not Altered in Men with Aortic Aneurysms

Lasse M. Obel 
1   Centre of Individualized Medicine in Arterial Disease (CIMA), Odense University Hospital, Odense, Denmark
2   Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
3   Department of Clinical Research, University of Southern Denmark, Odense, Denmark
,
Jes S. Lindholt
1   Centre of Individualized Medicine in Arterial Disease (CIMA), Odense University Hospital, Odense, Denmark
4   Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark
,
Axel C. Diederichsen
5   Department of Cardiology, Odense University Hospital, Odense, Denmark
,
Christian Kring
6   Department of Anesthesia and Intensive Care Medicine, Odense University Hospital, Svendborg, Denmark
,
Lars M. Rasmussen
1   Centre of Individualized Medicine in Arterial Disease (CIMA), Odense University Hospital, Odense, Denmark
2   Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
,
Anne B. Alnor
2   Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
3   Department of Clinical Research, University of Southern Denmark, Odense, Denmark
,
Pernille J. Vinholt 
2   Department of Clinical Biochemistry, Odense University Hospital, Odense, Denmark
3   Department of Clinical Research, University of Southern Denmark, Odense, Denmark
› Author Affiliations Funding This study was supported by the Region of Southern Denmark, the Elitary Research Center of Individualized Medicine in Arterial Diseases (CIMA), the Danish Council for Independent Research, the Danish Heart Foundation, Odense University Hospital, and the Helse Foundation.
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Introduction

Platelets play an important role in arterial diseases that extends beyond their traditional function in hemostasis and thrombosis.[1] The development and progression of ascending thoracic aortic dilations (ATADs) and abdominal aortic dilations (AADs) have been associated with increased platelet activation response.[1] [2] Consequently, platelets have been suggested as potential medical targets to slow expansion rates and reduce risk of ruptures.

This study aimed to evaluate if increased in vitro platelet aggregation and hyperresponsiveness of platelets were associated with the presence of ATAD and AAD, and to estimate potential correlations between platelet activation response and ascending and abdominal aortic diameters, respectively.

Note

All authors listed above take responsibility for the reliability and freedom from bias of data presented and interpreted in this article.




Publication History

Received: 23 June 2023

Accepted: 08 September 2023

Accepted Manuscript online:
12 September 2023

Article published online:
23 October 2023

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