False Laboratory Thyroid Function Tests after Biotin Treatment in a Neonate with Shock and Suspect of Metabolic Disorder

Introduction

Lactic acidosis in a sick infant can have multiple origins. It is predominantly caused by hypoperfusion of tissue due to cardiac failure, sepsis or hypovolemia. When acute disorders appear to be unlikely, mitochondrial diseases are such a group of very rare causes of lactic acidosis in neonates. Treatment with biotin – alongside with other vitamin and coenzyme substitution – may be considered to avoid harm, e. g. while obtaining in-depth laboratory results and genetic diagnostics. Thyroid parameters to exclude hypo- and hyperthyroidism are part of laboratory diagnostics.

Publication History

Article published online:
30 January 2024