Synthesis 2024; 56(05): 851-859
DOI: 10.1055/a-2226-4152
paper

Nitro Compounds/Alcohols as Oxidant/Reductant Pairs: A Practical Synthesis of Azo Compounds and Ketones

Renchao Ma
a   Institute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang 318000, P. R. of China
,
Ruiqin Zhang
b   School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. of China
,
Huanyi Qiu
b   School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. of China
,
Jianhui Xie
a   Institute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang 318000, P. R. of China
,
Yongmin Ma
a   Institute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Zhejiang 318000, P. R. of China
› Author Affiliations


Abstract

Herein, a practical and green method for the synthesis of azobenzenes and ketones is reported using nitro compounds/alcohols as oxidant/reductant pairs under basic conditions. Alcohols and nitro compounds are oxidized/reduced in the absence of any metal catalysts under mild conditions and good yields of the corresponding ketones and azobenzenes are achieved selectively. In addition, the alcohols can even be oxidized with KNO3 or NaNO2.

Supporting Information



Publication History

Received: 21 November 2023

Accepted after revision: 11 December 2023

Accepted Manuscript online:
11 December 2023

Article published online:
16 January 2024

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