Haptoglobin als Indikator für Erkrankungen in der Frühlaktation von Milchkühen unter besonderer Berücksichtigung der Eutergesundheit

Zusammenfassung

Haptoglobin (HP) ist als Akute-Phase-Protein Teil der unspezifischen Immunantwort und stellt einen aussagekräftigen Indikator für Entzündungszustände beim Rind dar. Die vorliegende Arbeit soll einen Überblick über bisherige Studienergebnisse zu Serum- und Milch-HP in Zusammenhang mit Erkrankungen in der Frühlaktation unter besonderer Berücksichtigung der Eutergesundheit geben. Bei entzündlichen Erkrankungen des Reproduktionstraktes, des Stoffwechsels und des Bewegungsapparates steigt HP im Blutserum an und kann als unspezifischer Indikator für Erkrankungen in der Frühlaktation dienen. Für die Differenzierung von gesunden und kranken Tieren stehen Grenzwerte zur Verfügung. Es besteht eine Korrelation zwischen HP in Blut und Milch. Die HP-Konzentration in Milch wird nicht nur von systemischen Erkrankungen beeinflusst, sondern das Euterepithel ist im Fall einer Infektion auch selbst in der Lage, HP zu synthetisieren. Bei Mastitis kann anhand der HP-Konzentration auf die Schwere der Erkrankung rückgeschlossen werden. Außerdem liefert die Höhe des HP-Anstiegs in Milch Hinweise auf das verursachende Pathogen. Für die Differenzierung von gesunden und subklinisch bzw. klinisch erkrankten Tieren stehen Grenzwerte für Milch-HP zur Verfügung.

Abstract

s an acute-phase protein Haptoglobin (HP) is part of the non-specific immune response and represents a strong indicator for inflammatory conditions in cattle. The purpose of this article is to provide an overview of previous study results on serum and milk HP related to diseases in early lactation with special consideration of udder health. During inflammatory diseases of the reproductive tract, metabolism and musculoskeletal system, HP increases in the serum and may serve as a non-specific indicator for diseases during early lactation. Threshold values are available for the differentiation of healthy from diseased animals. A correlation exists between HP in blood and milk. The HP concentration in milk is not only influenced by systemic disorders, as the udder epithelium is also independently capable of synthesizing HP in case of an infection. In mastitis, HP concentration may be used to estimate the severity of the disease. In addition, HP may provide certain suspicions regarding the causative pathogen. Threshold values for milk HP are available for the differentiation of healthy individuals from subclinically resp. clinically affected animals.

Schlüsselwörter

Akute-Phase-Protein - Akute-Phase-Reaktion - Bestandsbetreuung - Eutergesundheit - somatische Zellzahl - entzündliche Erkrankungen

Key words

Acute phase protein - acute phase reaction - herd health monitoring - udder health - somatic cell count - inflammatory diseases

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