physiopraxis 2024; 22(04): 34-37
DOI: 10.1055/a-2288-3165
Therapie

Kontroverse um Modic Changes – Ein Update

Mathias Rosenbaum

Über zehn Jahre nachdem Dr. Hanne Albert ihre bahnbrechenden Erkenntnisse veröffentlicht und die „Modic Antibiotic Spine Therapy“ initiiert hat, gilt es nun ein paar Fragen zu stellen. Waren die Erkenntnisse relevant? Hat es die Therapie von Menschen mit Modic 1 Changes grundlegend verändert? Ein Update.



Publication History

Article published online:
22 April 2024

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  • Literaturverzeichnis

  • 1 Albert HB, Manniche C. Modic changes following lumbar disc herniation. Eur Spine J 2007; 16: 977-982
  • 2 Albert HB, Kjaer P, Jensen TS. et al Modic changes, possible causes and relation to low back pain. Med Hypotheses 2008; 70: 361-368
  • 3 Albert HB, Sorensen JS, Christensen BS. et al Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): A double-blind randomized clinical controlled trial of efficacy. Eur Spine J 2013; 22: 697-707
  • 4 Moers S, Rosenbaum M. MAST know. Antibiotikatherapie bei Rückenschmerzen. physiopraxis 2014; 12: 34-37
  • 5 Modic MT, Steinberg PM, Ross JS. et al Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology 1988; 166: 193-199
  • 6 Manniche C, O’Neill S. New insights link low-virulent disc infections to the etiology of severe disc degeneration and Modic changes. Future Sci OA 2019; 05: FSO389
  • 7 Lama P, Zehra U, Balkovec C. et al Significance of cartilage endplate within herniated disc tissue. Eur Spine J 2014; 23: 1869-1877
  • 8 Kawaguchi K, Harimaya K, Matsumoto Y. et al Effect of cartilaginous endplates on extruded disc resorption in lumbar disc herniation. PLoS One 2018; 13: e0195946
  • 9 Bråten LCH, Rolfsen MP, Espeland A. et al Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial. BMJ 2019; 367: I5654
  • 10 Kristoffersen MP, Bråten LCH, Vetti N. et al Oedema on STIR modified the effect of amoxicillin as treatment for chronic low back pain with Modic changes-subgroup analysis of a randomized trial. Eur Radiol 2021; 31: 4285-4297
  • 11 Fritzell P, Welinder-Olsson C, Jönsson B. et al Bacteria: back pain, leg pain and Modic sign-a surgical multicentre comparative study. Eur Spine J 2019; 28: 2981-2989
  • 12 Ohrt-Nissen S, Fritz BG, Walbom J. et al Bacterial biofilms: a possible mechanism for chronic infection in patients with lumbar disc herniation – a prospective proof-of-concept study using fluorescence in situ hybridization. APMIS 2018; 126: 440-447
  • 13 Rajasekaran S, Soundararajan DCR, Nayagam SM. et al Modic changes are associated with activation of intense inflammatory and host defense response pathways – molecular insights from proteomic analysis of human intervertebral discs. Spine J 2022; 22: 19-38
  • 14 Granville Smith I, Danckert NP, Freidin MB. et al Evidence for infection in intervertebral disc degeneration: a systematic review. Eur Spine J 2022; 31: 414-430
  • 15 Määttä JH, Wadge S, MacGregor A. et al ISSLS prize winner: Vertebral endplate (modic) change is an independent risk factor for episodes of severe and disabling low back pain. Spine (Phila Pa 1976) 2015; 40: 1187-1193
  • 16 Latif R, Imran S, Ahmad I, Ilyas MS. et al Vertebral Endplate Changes Correlate with Presence of Cartilaginous Endplate in the Herniated Disc Tissue: Factor Predicting Failure of Conservative Treatment. Asian Spine J 2022; 16: 212-220
  • 17 Brinjikji XW, Diehn XFE, Jarvik JG. et al MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis. AJNR Am J Neuroradiol 2015; 36: 2394-2399
  • 18 Kjaer P, Korsholm L, Bendix T. et al Modic changes and their associations with clinical findings. Eur Spine J 2006; 15: 1312-1319
  • 19 Jensen OK, Nielsen CV, Sørensen JS. et al Type 1 Modic changes was a significant risk factor for 1-year outcome in sick-listed low back pain patients: A nested cohort study using magnetic resonance imaging of the lumbar spine. Spine J 2014; 14: 2568-2581
  • 20 Herlin C, Kjaer P, Espeland A. et al Modic changes—Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis. PLoS One 2018; 13: e0200677
  • 21 Kasch R, Truthmann J, Hancock MJ. et al Association of Lumbar MRI Findings with Current and Future Back Pain in a Population-based Cohort Study. Spine (Phila Pa 1976) 2022; 47: 201-211
  • 22 el Barzouhi A, Vleggeert-Lankamp CLAM, van der Kallen BF. et al Back pain’s association with vertebral end-plate signal changes in sciatica. Spine J 2014; 14: 225-233
  • 23 Udby PM, Bendix T, Ohrt-Nissen S. et al Modic Changes Are Not Associated with Long-term Pain and Disability: A Cohort Study with 13-year Follow-up. Spine (Phila Pa 1976) 2019; 44: 1186-1192
  • 24 Takatalo J, Karppinen J, Niinimäki J. et al Association of modic changes, Schmorl’s nodes, spondylolytic defects, high-intensity zone lesions, disc herniations, and radial tears with low back symptom severity among young Finnish adults. Spine (Phila Pa 1976) 2012; 37: 1231-1239
  • 25 Munir S, Freidin MB, Rade M. et al Endplate Defect Is Heritable, Associated with Low Back Pain and Triggers Intervertebral Disc Degeneration: A Longitudinal Study from TwinsUK. Spine (Phila Pa 1976) 2018; 43: 1496-1501
  • 26 Mok FPS, Samartzis D, Karppinen J. et al ISSLS Prize Winner: Prevalence, Determinants, and Association of Schmorl Nodes of the Lumbar Spine With Disc Degeneration A Population-Based Study of 2449 Individuals. Spine (Phila Pa 1976) 2010; 35: 1944-1952
  • 27 Mu X, Peng W, Ou Y. et al Non-surgical therapy for the treatment of chronic low back pain in patients with Modic changes: A systematic review of the literature. Heliyon. 2022; 08: e09658
  • 28 Jensen RK, Leboeuf-Yde C, Wedderkopp N. et al Rest versus exercise as treatment for patients with low back pain and Modic changes. A randomized controlled clinical trial. BMC Med 2012; 10: 22
  • 29 Annen M, Peterson C, Leemann S. et al Comparison of Outcomes in MRI Confirmed Lumbar Disc Herniation Patients with and Without Modic Changes Treated with High Velocity, Low Amplitude Spinal Manipulation. J Manipulative Physiol Ther 2016; 39: 200-209
  • 30 Boutevillain L, Bonnin A, Chabaud A. et al Short-term pain evolution in chronic low back pain with Modic type 1 changes treated by a lumbar rigid brace: A retrospective study. Ann Phys Rehabil Med 2019; 62: 3-7