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Z Gastroenterol 2024; 62(08): 1207-1210
DOI: 10.1055/a-2293-7813
Originalarbeit

The four seasons of pancreatitis – Etiology of acute pancreatitis during the course of the year

Die vier Jahreszeiten der akuten Pankreatitis – Saisonalität der Pankreatitis-Ätiologien im Jahresverlauf
Simon Sirtl 
1   Department of Medicine II, LMU University Hospital, Munich, Germany
,
Eric Hohmann
1   Department of Medicine II, LMU University Hospital, Munich, Germany
,
Georg Beyer
1   Department of Medicine II, LMU University Hospital, Munich, Germany
,
Jacob Hamm
2   Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Centre Goettingen, Goettingen, Germany
,
Albrecht Neesse
2   Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Centre Goettingen, Goettingen, Germany
,
Christoph Ammer-Herrmenau
2   Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Centre Goettingen, Goettingen, Germany
› Author AffiliationsSS is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 413635475 – and the LMU Munich Clinician Scientist Program (MCSP). CAH and JH are funded by the University Medical center Goettingen/ DFG Clinician Scientist Program.
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Abstract

Background/Objectives Whether seasonality is a factor that influences the incidence of acute pancreatitis (AP) is an under-investigated area. If seasonal incidence peaks can be detected, specifically with regard to biliary pancreatitis, has so far been answered in contradictory ways in the literature.

Methods All AP cases from two tertiary German referral centers were identified between 2016 and 2022 based on ICD-10 discharge codes. The χ2 test for goodness of fit was applied to test significant differences in monthly and seasonal distributions of AP admissions.

Results In total, 3597 AP cases were included. We observed significantly more idiopathic and biliary cases in May to July (p-values 0.041 and 0.027, respectively). Furthermore, most drug-induced APs were identified during the winter months (p-value 0.006). Moreover, there was a significant peak of alcohol-induced pancreatitis in summer and fall (p-value 0.038).

Conclusions Our data indicate a seasonal impact on AP incidences for certain etiologies.

Zusammenfassung

Hintergrund Ob Saisonalität einen die Inzidenz der akuten Pankreatitis beeinflussenden Faktor darstellt, ist bisher nicht ausreichend untersucht. Speziell mit Blick auf mögliche saisonale Peaks der biliären Pankreatitis finden sich in der Literatur widersprüchliche Daten.

Methodik Alle stationären Pankreatitis-Fälle aus den Jahren 2016–2022 von zwei großen, universitären Pankreaszentren (LMU Klinikum München + Uniklinik Göttingen) wurden basierend auf den ICD-10-Codierungen unter Berücksichtigung der jeweiligen Pankreatitis-Ätiologie analysiert. Mittels χ²-Goodness-of-Fit-Test wurde die monatliche und saisonale Verteilung der Pankreatitis-Krankenhausaufnahmen stratifiziert nach den zugrundeliegenden Ätiologien untersucht.

Ergebnisse 3597 Pankreatitis-Fälle wurden final ausgewertet. Es zeigten sich signifikant mehr Fälle von idiopathischer und biliärer Pankreatitis in den Monaten Mai und Juli (p = 0.041 und 0.027). Die meisten Medikamenten-assoziierten Pankreatitiden fanden sich im Winter (p = 0.006). Signifikante Peaks der Alkohol-induzierten Pankreatitis wurden im Sommer und Herbst detektiert (p = 0.038).

Schlussfolgerung Für bestimmte Pankreatitis-Ätiologien lässt sich ein saisonaler Einfluss bezogen auf die Inzidenz feststellen.

Keywords

Acute pancreatitis - seasonality - idiopathic pancreatitis - biliary pancreatitis

Schlüsselwörter

Akute Pankreatitis - Saisonalität - Idiopathische Pankreatitis - Biliäre Pankreatitis

Supplementary Material



Publication History

Received: 04 December 2023

Accepted after revision: 19 March 2024

Article published online:
15 May 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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