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Synthesis
DOI: 10.1055/a-2295-8639
DOI: 10.1055/a-2295-8639
paper
Special Issue PSRC-10 (10th Pacific Symposium on Radical Chemistry)
Denitrative Sulfonylation of Nitroarenes with Sodium Sulfinates
J.D.L. and B.D.C. thank The University of Manchester for PhD studentships. M.Č. thanks the National Scholarship Programme of the Slovak Republic (Slovak Academic Information Agency) and the Slovak University of Technology in Bratislava for financial support. T.D.H. thanks AstraZeneca for a PhD studentship. E.R.X.L. thanks the EPSRC Centre for Doctoral Training in Integrated Catalysis (EPSRC grant: EP/S023755/1) for a PhD studentship.
Abstract
A one-step method to convert nitroarenes into aryl sulfones under operationally simple, transition-metal-free conditions is described. A range of nitroarenes were reacted with sodium sulfinates and caesium carbonate in N,N′-dimethylpropyleneurea to afford aryl sulfones in up to 83% yield.
Key words
denitrative functionalisation - sulfonylation - nitroarenes - aryl sulfones - transition-metal-freeSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2295-8639.
- Supporting Information
Publication History
Received: 16 February 2024
Accepted after revision: 27 March 2024
Accepted Manuscript online:
27 March 2024
Article published online:
15 April 2024
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For reviews, see:
For general reviews on the synthesis of aryl sulfones, see:
For examples of nucleophilic substitution reactions with sulfinate salts, see:
For examples of metal-catalysed coupling reactions with sulfinate salts, see:
For reviews on denitrative functionalisation, see:
For selected examples of denitrative functionalisation reactions, see: