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DOI: 10.1055/a-2334-6194
Do Disease Parameters Related to Primary Sjögren's Syndrome have an Impact on the Severity of Co-Existing Fibromyalgia Syndrome or Vice Versa?
Haben Krankheitsparameter im Zusammenhang mit dem primären Sjögren-Syndrom einen Einfluss auf die Schwere des gleichzeitig bestehenden Fibromyalgie-Syndroms oder umgekehrt?
Abstract
Objectives We aimed to examine whether primary Sjögren's syndrome (pSS)-related parameters may affect the severity of co-existing fibromyalgia syndrome (FMS) in pSS patients or vice versa; co-existing FMS might have an influence on the severity of sicca symptoms and disease activity measurements in pSS.
Method Our study included a total of 49 pSS patients (24 with concomitant FMS; 25 without FMS) and 30 patients with primary FMS (pFMS). The EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) and the EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) were used to evaluate pSS symptoms and disease activity. Sicca symptom severity (SSS) scores were recorded on a visual analogue scale for pSS patients. A minor salivary gland biopsy was performed in 34 pSS patients. The Revised Fibromyalgia Impact Questionnaire (FIQR) was used to evaluate the total spectrum of fibromyalgia-related problems.
Results There was no statistically significant difference between disease activity measurements (ESSDAS, ESSPRI) in pSS patients with FMS and pSS patients (p=0.913, p=0.952, respectively). However, SSS scores were significantly higher in pSS patients with FMS than in pSS patients (p=0.045). There was no statistically significant difference between pFMS and pSS patients with FMS in terms of FIQR scores (p=0.149).
Conclusions It was demonstrated that the severity of fibromyalgia assessed by FIQR is comparable between both groups.
Publication History
Article published online:
11 July 2024
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References
- 1 Iannuccelli C, Spinelli FR, Guzzo MP. et al. Fatigue and widespread pain in systemic lupus erythematosus and Sjögren’s syndrome: symptoms of the inflammatory disease or associated fibromyalgia?. Clinical and Experimental Rheumatology 2012; 30: 117-121 https://pubmed.ncbi.nlm.nih.gov/23261010/
- 2 Ostuni P, Botsios C, Sfriso P. et al. Fibromyalgia in Italian patients with primary Sjögren’s syndrome. Joint Bone Spine 2002; 69: 51-57
- 3 Ostuni P, Botsios C, Sfriso P. et al. [Prevalence and clinical features of fibromyalgia in systemic lupus erythematosus, systemic sclerosis and Sjögren’s syndrome]. Minerva Medica 2002; 93: 203-209 https://pubmed.ncbi.nlm.nih.gov/12094151
- 4 Omdal R, Mellgren SI, Norheim KB. Pain and fatigue in primary Sjögren’s syndrome. Rheumatology 2019; 60: 3099-3106
- 5 Applbaum E, Lichtbroun A. Novel Sjögren’s autoantibodies found in fibromyalgia patients with sicca and/or xerostomia. Autoimmunity Reviews 2019; 18: 199-202
- 6 Giles I. Fatigue in primary Sjogren’s syndrome: Is there a link with the fibromyalgia syndrome?. Annals of the Rheumatic Diseases 2000; 59: 875-878
- 7 Shiboski CH, Shiboski SC, Seror R. et al. 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren’s Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts. Arthritis & Rheumatology 2016; 69: 35-45
- 8 Wolfe F, Clauw DJ, Fitzcharles MA. et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Seminars in Arthritis and Rheumatism 2016; 46: 319-329
- 9 Seror R, Ravaud P, Mariette X. et al. EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI): development of a consensus patient index for primary Sjögren’s syndrome. Annals of the Rheumatic Diseases 2011; 70: 968-972
- 10 Seror R, Bowman SJ, Brito-Zeron P. et al. EULAR Sjögren’s syndrome disease activity index (ESSDAI): a user guide. RMD Open 2015; 1
- 11 Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjogren’s disease. Journal of Clinical Pathology 1968; 21: 656-660
- 12 Bennett RM, Friend R, Jones KD. et al. The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties. Arthritis Research & Therapy 2009; 11: R120
- 13 Torrente-Segarra V, Corominas H, Sánchez-Piedra C. et al. Fibromyalgia prevalence and associated factors in primary Sjögren’s syndrome patients in a large cohort from the Spanish Society of Rheumatology registry (SJOGRENSER). Clinical and Experimental Rheumatology 2017; 35: 28-34 https://pubmed.ncbi.nlm.nih.gov/28240585
- 14 Vitali C, Tavoni A, Neri R. et al. Fibromyalgia Features in Patients with Primary Sjögren’s Syndrome: Evidence of a Relationship with Psychological Depression. Scandinavian Journal of Rheumatology 1989; 18: 21-27
- 15 Dohrenbusch R, Grüterich M, Genth E. [Fibromyalgia and Sjögren syndrome--clinical and methodological aspects]. Zeitschrift Fur Rheumatologie 1996; 55: 19-27 https://pubmed.ncbi.nlm.nih.gov/8868147
- 16 Tishler M, Barak Y, Paran D. et al. Sleep disturbances, fibromyalgia and primary Sjögren’s syndrome. Clinical and Experimental Rheumatology 1997; 15: 71-74 https://pubmed.ncbi.nlm.nih.gov/9093776
- 17 van Oers ML, Bossema ER, Thoolen BJ. et al. Variability of fatigue during the day in patients with primary Sjögren’s syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Clinical and Experimental Rheumatology 2010; 28: 715-721 https://pubmed.ncbi.nlm.nih.gov/20863446
- 18 Theander L, Strombeck B, Mandl T. et al. Sleepiness or fatigue? Can we detect treatable causes of tiredness in primary Sjogren’s syndrome. Rheumatology 2010; 49: 1177-1183
- 19 Price EJ. Dry eyes and mouth syndrome – a subgroup of patients presenting with sicca symptoms. Rheumatology 2002; 41: 416-422
- 20 Mariette X, Criswell LA. Primary Sjögren’s Syndrome. Solomon CG, ed. New England Journal of Medicine. 2018. 378. 931-939
- 21 Choi BY, Oh HJ, Lee YJ. et al. Prevalence and clinical impact of fibromyalgia in patients with primary Sjögren’s syndrome. Clinical and Experimental Rheumatology 2016; 34: S9-S13 https://pubmed.ncbi.nlm.nih.gov/26315451
- 22 Price EJ, Rauz S, Tappuni AR. et al. The British Society for Rheumatology guideline for the management of adults with primary Sjögren’s Syndrome. Rheumatology 2017; 56: 1828-1828
- 23 Ramos-Casals M, Brito-Zerón P, Bombardieri S. et al. EULAR recommendations for the management of Sjögren’s syndrome with topical and systemic therapies. Annals of the Rheumatic Diseases 2020; 79: 3-18
- 24 Bournia VK, Vlachoyiannopoulos PG. Subgroups of Sjögren syndrome patients according to serological profiles. Journal of Autoimmunity 2012; 39: 15-26
- 25 UpToDate. Clinical manifestations of Sjögren’s disease: Extraglandular disease. Online: https://www.uptodate.com/contents/clinical-manifestations-of-sjogrens-syndrome-extraglandular-disease#H53038499 last accessed: 27.11. 2023
- 26 UpToDate. Clinical manifestations of Sjögren’s disease: Extraglandular disease. Online: https://www.uptodate.com/contents/diagnosis-and-classification-of-sjogrens-disease# last accessed: 27.11. 2023.
- 27 Wicheta S, Van T, Faquin WC. et al. Discrepancies in Interpretation of the Minor Salivary Gland Biopsy in the Diagnosis of Sjögren Syndrome. Journal of Oral and Maxillofacial Surgery 2019; 77: 1628-1635
- 28 Guellec D, Cornec D, Jousse-Joulin S. et al. Diagnostic value of labial minor salivary gland biopsy for Sjögren’s syndrome: A systematic review. Autoimmunity Reviews 2013; 12: 416-420
- 29 Karageorgas T, Fragioudaki S, Nezos A. et al. Fatigue in Primary Sjögren’s Syndrome: Clinical, Laboratory, Psychometric, and Biologic Associations. Arthritis Care & Research 2015; 68: 123-131