Synthesis and Biological Evaluation of Novel Coumarin Derivatives Bearing a Sulfonamide Moiety as Antiviral and Antibacterial Agent

Song Bai; Lin Liu; Rong Wu; Shouyin Tang; Suran Wan; Fang Wang; Xian Wei; Lijun Chen; Shunyi Xu; Miao Li

doi:10.1055/a-2361-6916

Synlett, Inhaltsverzeichnis

Synlett 2025; 36(05): 541-545
DOI: 10.1055/a-2361-6916

letter

Synthesis and Biological Evaluation of Novel Coumarin Derivatives Bearing a Sulfonamide Moiety as Antiviral and Antibacterial Agent

Song Bai ∗

^aGuiyang Gui Orchard Ecological Environment Research Center, Guizhou Industry Polytechnic College, Guiyang, 550008, P. R. of China

^bSchool of Chemical Engineering, Guizhou Institute of Technology, Guiyang, 550003, P. R. of China

^cState Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Guizhou University, Guiyang, 550025, P. R. of China

,

Lin Liu

^aGuiyang Gui Orchard Ecological Environment Research Center, Guizhou Industry Polytechnic College, Guiyang, 550008, P. R. of China

,

Rong Wu

^aGuiyang Gui Orchard Ecological Environment Research Center, Guizhou Industry Polytechnic College, Guiyang, 550008, P. R. of China

,

Shouyin Tang

^aGuiyang Gui Orchard Ecological Environment Research Center, Guizhou Industry Polytechnic College, Guiyang, 550008, P. R. of China

,

Suran Wan

^aGuiyang Gui Orchard Ecological Environment Research Center, Guizhou Industry Polytechnic College, Guiyang, 550008, P. R. of China

,

Fang Wang

^aGuiyang Gui Orchard Ecological Environment Research Center, Guizhou Industry Polytechnic College, Guiyang, 550008, P. R. of China

,

Xian Wei

^bSchool of Chemical Engineering, Guizhou Institute of Technology, Guiyang, 550003, P. R. of China

,

Lijun Chen

^bSchool of Chemical Engineering, Guizhou Institute of Technology, Guiyang, 550003, P. R. of China

,

Shunyi Xu

^aGuiyang Gui Orchard Ecological Environment Research Center, Guizhou Industry Polytechnic College, Guiyang, 550008, P. R. of China

,

Miao Li∗

^aGuiyang Gui Orchard Ecological Environment Research Center, Guizhou Industry Polytechnic College, Guiyang, 550008, P. R. of China

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Abstract

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Abstract

Twenty novel 4-bromocoumarin derivatives bearing a sulfonamide moiety were designed and synthesized. Their antiviral and antibacterial activities were systematically evaluated. The test results show that all the target compounds possess moderate to excellent antiviral and antibacterial activities. Among all target compounds, one compound exhibited good antiviral activity against TMV, CMV, and PVY, which is superior to ribavirin. Moreover, two target compounds exhibited good in vitro antibacterial activity against Psa, with an EC₅₀ value of 44.9 mg/L and 49.3 mg/L, respectively, which were better than thiodiazole copper and zinc thiazole, with an EC₅₀ value of 56.3 mg/L and 50.2 mg/L, respectively. The results provide insights for the development of multifunctional pesticides.

Key words

coumarin derivatives - antiviral activity - antibacterial activity - TMV - CMV - PVY - Xoo - Psa

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Referenzen

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