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J Neurol Surg B Skull Base
DOI: 10.1055/a-2374-9868
Original Article

Olfactory Groove Meningiomas and the Association with Postoperative Weight Loss

Stephanie A. Armstrong
1   Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
,
Timothy F. Boerger
1   Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
,
Brandon Laing
1   Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
,
Samon Tavakoli
1   Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
,
Kaitlin Goetschel
1   Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
,
Stephanie Cheok
1   Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
,
Nathan Zwagerman
1   Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
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Abstract

Objective Olfactory groove meningiomas (OGM) commonly present with olfactory deficits and compression of the frontal lobes. Given the relationship to dietary behaviors, our objective was to evaluate the relationship between OGMs and postoperative weight loss.

Methods Retrospective review of primary resection of meningiomas between 2017 and 2023 at a single institution was conducted. Neurofibromatosis type 2, pregnancy, weight loss medications, or surgeries were excluded. Data collection included preoperative body mass index (preBMI) and postoperative BMI (poBMI) at 3 to 6 and 12 months. Percent BMI change (pcBMI) was calculated by (poBMI − preBMI/preBMI × 100%). IBM SPSS Statistics (Version 27) was used for descriptive statistics and stepwise multiple linear regression.

Results Ninety-eight patients met inclusion with a mean age of 57.58 years. Three groups were stratified by location: OGM (n = 15), anterior cranial fossa excluding OGM (ACF; n = 24), and other (OTH; n = 59). Olfactory dysfunction was present in 53.8% of the OGMs. OGM presented with significantly larger lesions (57.25 ± 55.98 mm3) and a higher preBMI (34.58 ± 7.41 kg/m2) than ACF and OTH. A greater pcBMI was seen in OGM at both timepoints (−7.74%, −8.73%). OGM location, tumor volume, and preBMI were found significant on univariate analysis (p < 0.05) and included in multiple linear regression. All regression models were significant (p = 0.001). Location significantly added to the prediction at 3 to 6 and 12 months as well as preBMI at 12 months. In a subanalysis of ACF and OGM, OGM location was significantly associated with negative pcBMI at 3 to 6 and 12 months.

Conclusion OGMs are associated with higher preoperative weight and greater weight loss postoperatively compared with other locations.

Keywords

olfactory groove - meningioma - body mass index - weight loss - olfaction - mini-orbitozygomatic approach

Previous Presentation

Poster Presentation at the North American Skull Base Society Annual Meeting February 16 to 18, 2024.




Publication History

Received: 31 May 2024

Accepted: 25 July 2024

Accepted Manuscript online:
29 July 2024

Article published online:
14 August 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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