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Planta Med 2024; 90(12): 959-970
DOI: 10.1055/a-2376-6380
Formulation and Delivery Systems
Original Papers

Design and Development of a Self-nanoemulsifying Drug Delivery System for Co-delivery of Curcumin and Naringin for Improved Wound Healing Activity in an Animal Model

Ajmal Hayat
1   Department of Pharmacy, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan
,
Ismail Shah‡
1   Department of Pharmacy, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan
,
Abdul Jabbar
2   International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan
,
Shafi Ullah
3   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Superior University, Lahore, Pakistan
,
Muhammad Raza Shah
2   International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan
,
Muhammad Shafique‡
4   Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia
,
Aziz Balouch
2   International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan
,
Farah Gul
5   Pharmacology Section MBC, PCSIR Laboratories Complex, Peshawar, Pakistan
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Abstract

The present study endeavored to design and develop a self-nanoemulsifying drug delivery system to improve the solubility and dermatological absorption of curcumin and naringin. Curcumin and naringin-loaded self-nanoemulsifying drug delivery system formulations were developed using aqueous phase titration. Phase diagrams were used to pinpoint the self-nanoemulsifying drug delivery system zones. Tween 80 and Labrasol (surfactants), Transcutol (cosurfactant), and cinnamon oil were chosen from a large pool of surfactants, cosurfactants, and oils based on their solubility and greatest nano-emulsion region. Fourier transform infrared spectroscopy, zeta sizer, and atomic force microscopy were used to characterize the optimized formulations and test for dilution and thermodynamic stability. The optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated the following characteristics: polydispersity index (0.412 ± 0.03), % transmittance (97%), particle size (212.5 ± 05 nm), zeta potential (− 25.7 ± 1.80 mV) and having a smooth and spherical droplet shape, as shown by atomic force microscopy. The ability of their combined formulation to cure wounds was tested in comparison to pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Upon topical administration, the optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated significant wound healing activity in comparison with a pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Based upon this result, we assume that skin penetration was increased by using the optimized curcumin-naringin-self-nanoemulsifying drug delivery system with enhanced solubility.

Keywords

SNEDDS - curcumin - Curcuma longa - Zingiberaceae - naringin - Citrus reticulata - Rutaceae - wound healing - phase diagrams - thermodynamic stability - topical administration


Publication History

Received: 27 March 2024

Accepted after revision: 30 July 2024

Accepted Manuscript online:
30 July 2024

Article published online:
15 August 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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