Klin Padiatr 2025; 237(02): 81-87
DOI: 10.1055/a-2380-2878
Original Article

Management of RSV Bronchiolitis in Outpatient Setting

Management der RSV Bronchiolitis in der kinderärztlichen Praxis
1   Pediatrics, Section of Neonatology, Allergology, Pulmonology and Pediatric Intensive Care and Research Centre Neurosensory Science, Carl von Ossietzky University of Oldenburg Faculty VI Medicine and Health Sciences, Oldenburg, Germany
,
Lea Sandmann
1   Pediatrics, Section of Neonatology, Allergology, Pulmonology and Pediatric Intensive Care and Research Centre Neurosensory Science, Carl von Ossietzky University of Oldenburg Faculty VI Medicine and Health Sciences, Oldenburg, Germany
,
Simon Ritter
2   Pediatric Pneumology, Hannover Medical School, Hannover, Germany
,
Axel Heep
1   Pediatrics, Section of Neonatology, Allergology, Pulmonology and Pediatric Intensive Care and Research Centre Neurosensory Science, Carl von Ossietzky University of Oldenburg Faculty VI Medicine and Health Sciences, Oldenburg, Germany
,
Holger Köster
1   Pediatrics, Section of Neonatology, Allergology, Pulmonology and Pediatric Intensive Care and Research Centre Neurosensory Science, Carl von Ossietzky University of Oldenburg Faculty VI Medicine and Health Sciences, Oldenburg, Germany
,
Martin Wetzke
2   Pediatric Pneumology, Hannover Medical School, Hannover, Germany
,
Matthias Lange
1   Pediatrics, Section of Neonatology, Allergology, Pulmonology and Pediatric Intensive Care and Research Centre Neurosensory Science, Carl von Ossietzky University of Oldenburg Faculty VI Medicine and Health Sciences, Oldenburg, Germany
› Author Affiliations

Abstract

Seasonal respiratory syncytial virus (RSV) lower respiratory infections (RSV-LRI) and bronchiolitis in children remain a high burden to medical facilities. Studies evaluating the practical approach in outpatient settings are scarce. We conducted a survey to provide an insight into management in pediatric offices in Germany. Invitations for participation in an online survey were sent to 623 providers of pediatric primary care via email. Recipients were randomly chosen from national databanks based on zip codes. The response rate was 16,2%, n=92 (14,7%) questionnaires were fully answered and analyzed. 93,5% (n=86) are board certified pediatricians. In outpatient setting, every second patient with suspected or confirmed RSV-LRI is presented three times or more. 40,7% of our participants refer less than 10% of all patients to hospital, 83,7% refer less than one third (<30%). 33,7% of all participants never perform virological testing in suspected cases of RSV-LRI. More than 50% of all participants prescribe bronchodilators, hypertonic saline inhalation is prescribed by 17,4%. Antibiotics are prescribed in less than 10% of all cases of RSV-LRI. About 3/4 ask for a clearer, more conclusive guideline regarding prophylaxis. The diagnostic approach varies significantly. Although not recommended in international guidelines, bronchodilators are still frequently used. Considering emerging options for passive immunization, broader inclusion criteria into immunization regimes are requested by the participants. More conclusive guidelines and recommendations could further improve the management of outpatient RSV-LRI in children.

Zusammenfassung

Saisonale Infektionen mit dem Respiratorischen Synzytialvirus (RSV) bei Kindern sind eine große Belastung für medizinische Einrichtungen. Während die stationäre Versorgung gut untersucht ist, gibt es zum Vorgehen im ambulanten Bereich bisher nur wenig Erkenntnisse. Unsere Umfrage ermöglicht einen Einblick in das praktische Management von RSV Infektionen und der Bronchiolitis in pädiatrischen Praxen in Deutschland. Einladungen zur Teilnahme wurden deutschlandweit per E-Mail an 623 kinderärztliche Praxen geschickt. Die Empfänger wurden nach dem Zufallsprinzip aus nationalen Postleitzahlen-Datenbanken ausgewählt. Die Rücklaufquote betrug 16,2 Prozent, n=92 (14,7%) Fragebögen wurden vollständig beantwortet und gingen in die Auswertung ein. 93,5% (n=86) der Teilnehmer sind Fachärzte für Kinder- und Jugendmedizin. Im ambulanten Bereich wird jeder zweite Patient mit RSV-Infektion drei Mal oder häufiger vorgestellt. 40,7% der Befragten weisen weniger als 10% aller Patienten, 83,7% weniger als ein Drittel (<30%) in die Klinik ein. 33,7% aller Teilnehmer führen bei Verdacht auf RSV-Infektion nie einen virologischen Test durch. Mehr als 50% aller Teilnehmer verschreiben Bronchodilatatoren, 17,4% hypertone Kochsalzinhalation. Antibiotika werden in weniger als 10% der Fälle verschrieben. Etwa 3/4 fordern eine klarere, schlüssigere Leitlinie zur Prophylaxe. Der diagnostische Ansatz variiert. Inhalative Bronchodilatatoren werden häufig eingesetzt, auch wenn sie in internationalen Leitlinien nicht empfohlen werden. Angesichts neuer Möglichkeiten der passiven Immunisierung wird von den Befragten mehrheitlich eine breitere Indikationsstellung hierzu gefordert. Das ambulante Management von RSV-Infektionen könnte durch konkretere Empfehlungen verbessert werden.



Publication History

Article published online:
20 September 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Li Y, Wang X, Blau DM. et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. The Lancet 2022; 399: 2047-2064
  • 2 Thomas E, Mattila J-M, Lehtinen P. et al. Burden of Respiratory Syncytial Virus Infection During the First Year of Life. J Infect Dis 2021; 223: 811-817
  • 3 Wildenbeest JG, Billard M-N, Zuurbier RP. et al. The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study. Lancet Respir Med 2023; 11: 341-353
  • 4 Hall CB, Weinberg GA, Blumkin AK. et al. Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age. Pediatrics 2013; 132: e341-e348
  • 5 Cai W, Dürrwald R, Biere B. et al. Determination of respiratory syncytial virus epidemic seasons by using 95% confidence interval of positivity rates, 2011–2021, Germany. Influenza Other Respir Viruses 2022; 16: 854-857
  • 6 Bardsley M, Morbey RA, Hughes HE. et al. Epidemiology of respiratory syncytial virus in children younger than 5 years in England during the COVID-19 pandemic, measured by laboratory, clinical, and syndromic surveillance: a retrospective observational study. Lancet Infect Dis 2023; 23: 56-66
  • 7 Stamm P, Sagoschen I, Weise K. et al. Influenza and RSV incidence during COVID-19 pandemic-an observational study from in-hospital point-of-care testing. Med Microbiol Immunol (Berl) 2021; 210: 277-282
  • 8 Delestrain C, Danis K, Hau I. et al. Impact of COVID-19 social distancing on viral infection in France: A delayed outbreak of RSV. Pediatr Pulmonol 2021; 56: 3669-3673
  • 9 Buchholz U, Buda S, Lehfeld A-S. et al. GrippeWeb – Daten des Wochenberichts. 2024
  • 10 Tong S, Amand C, Kieffer A. et al. Incidence of respiratory syncytial virus related health care utilization in the United States. J Glob Health 2020; 10: 020422
  • 11 Hall CB, Weinberg GA, Iwane MK. et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009; 360: 588-598
  • 12 Heikkinen T, Ojala E, Waris M. Clinical and Socioeconomic Burden of Respiratory Syncytial Virus Infection in Children. J Infect Dis 2017; 215: 17-23
  • 13 Bourgeois FT, Valim C, Wei JC. et al. Influenza and other respiratory virus-related emergency department visits among young children. Pediatrics 2006; 118: e1-e8
  • 14 Paramore LC, Mahadevia PJ, Piedra PA. Outpatient RSV lower respiratory infections among high-risk infants and other pediatric populations. Pediatr Pulmonol 2010; 45: 578-584
  • 15 Paramore LC, Ciuryla V, Ciesla G. et al. Economic impact of respiratory syncytial virus-related illness in the US: an analysis of national databases. PharmacoEconomics 2004; 22: 275-284
  • 16 Fauroux B, Simões EAF, Checchia PA. et al. The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood. Infect Dis Ther 2017; 6: 173-197
  • 17 Stein RT, Zar HJ. RSV through the COVID-19 pandemic: Burden, shifting epidemiology, and implications for the future. Pediatr Pulmonol 2023; 58: 1631-1639
  • 18 Rosas-Salazar C, Chirkova T, Gebretsadik T. et al. Respiratory syncytial virus infection during infancy and asthma during childhood in the USA (INSPIRE): a population-based, prospective birth cohort study. The Lancet 2023; 401: 1669-1680
  • 19 Wang X, Li Y, Vazquez Fernandez L. et al. Respiratory Syncytial Virus-Associated Hospital Admissions and Bed Days in Children <5 Years of Age in 7 European Countries. J Infect Dis 2022; 226: S22-S28
  • 20 Shi T, Vennard S, Mahdy S. et al. Risk Factors for Poor Outcome or Death in Young Children With Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection: A Systematic Review and Meta-Analysis. J Infect Dis 2022; 226: S10-S16
  • 21 Cunningham S, Rodriguez A, Adams T. et al. Oxygen saturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial. The Lancet 2015; 386: 1041-1048
  • 22 Dafydd C, Saunders BJ, Kotecha SJ. et al. Efficacy and safety of high flow nasal oxygen for children with bronchiolitis: systematic review and meta-analysis. BMJ Open Respir Res 2021; 8: e000844
  • 23 Ralston SL, Lieberthal AS, Meissner HC. et al. Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis. Pediatrics 2014; 134: e1474-e1502
  • 24 Zhang L, Mendoza-Sassi RA, Wainwright CE. et al. Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev 2023;
  • 25 Barben J, Kuehni CE. Hypertonic saline for acute viral bronchiolitis: take the evidence with a grain of salt. Eur Respir J 2014; 44: 827-830
  • 26 Chatterjee A, Mavunda K, Krilov LR. Current State of Respiratory Syncytial Virus Disease and Management. Infect Dis Ther 2021; 10: 5-16
  • 27 Lange M, Happle C, Hamel J. et al. Non-Appearance of the RSV Season 2020/21 During the COVID-19 Pandemic–Prospective, Multicenter Data on the Incidence of Respiratory Syncytial Virus (RSV) Infection. Dtsch Arzteblatt Int 2021; 118: 561-562
  • 28 Perez A, Lively JY, Curns A. et al. Respiratory Virus Surveillance Among Children with Acute Respiratory Illnesses — New Vaccine Surveillance Network, United States, 2016–2021. Morb Mortal Wkly Rep 2022; 71: 1253-1259
  • 29 Gadomski AM, Scribani MB. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev 2014;
  • 30 Fernandes RM, Bialy LM, Vandermeer B. et al. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev 2013;
  • 31 Liese J, Forster J, Herting E. S2k-Leitlinie AWMF 048 – 012 „Leitlinie zur Prophylaxe von schweren Erkrankungen durch Respiratory Syncytial Virus (RSV) bei Risikokindern. Aktualisierung 2023 / Version 5.0. 2023