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Synlett 2024; 35(20): 2503-2507
DOI: 10.1055/a-2388-9578
DOI: 10.1055/a-2388-9578
letter
Special Issue to Celebrate the 75th Birthday of Prof. B. C. Ranu
Sustainable N-Formylation of Anilines: Harnessing Aleuritic Acid as a Renewable Formyl Source
H.A.V. is thankful to the Department of Science and Technology (DST), Ministry of Science and Technology, India, for the award of INSPIRE Fellowship and G.B. is thankful to the University Grants Commission, New Delhi, India for the award of Senior Research Fellowship. We are also thankful to the Central Salt and Marine Chemicals Research Institute, Council of Scientific and Industrial Research (CSIR-CSMCRI, MLP-074 and HCP-049) for partial financial support.
Dedicated to Professor B. C. Ranu on the occasion of his 75th birthday celebration
Abstract
N-Formylation of anilines using a renewable aleuritic acid as an eco-friendly and sustainable formylating source has been developed. para-Substituted anilines generally provided good yields, while moderate yields were observed with meta- and ortho-substituted derivatives. In situ generated formic acid through oxidative cleavage of aleuritic acid serve as a formyl source, which has been confirmed through control experiments.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2388-9578.
- Supporting Information
Publication History
Received: 27 June 2024
Accepted after revision: 15 August 2024
Accepted Manuscript online:
15 August 2024
Article published online:
18 September 2024
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