Platinum-Catalyzed Deoxygenation of N-Acyloxyamines

Abstract

We report a Pt-catalyzed double deoxygenative transformation of N-acyloxyamines, employing PtCl₂ catalyst without external ligand under mild conditions. This method facilitates efficient C–N bond formation and can be used to synthesize a broad spectrum of alkylated secondary and tertiary amines with excellent yields. The adaptability and effectiveness of this approach highlight the potential of platinum catalysis to extend beyond traditional synthetic boundaries.

Key words

platinum - acyloxyamine - deoxygenation - reduction - silane - C–N coupling

Publication History

Received: 20 August 2024

Accepted after revision: 05 September 2024

Accepted Manuscript online:
05 September 2024

Article published online:
26 September 2024

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