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Int J Sports Med 2025; 46(01): 22-31
DOI: 10.1055/a-2412-3410
Physiology & Biochemistry

Serum Metabolome Signature Response to Different Types of Resistance Training

Joshua Frederik Feuerbacher 
1   Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany
2   Department of Sports Medicine and Exercise Therapy, Chemnitz University of Technology, Chemnitz, Germany
,
Runtan Cheng
3   Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
4   Faculty of Physical Education, Shanghai Jiao Tong University, Shanghai, China
,
Milan Sedliak
5   Department of Biological and Medical Sciences, Faculty of Physical Education, Comenius University in Bratislava, Bratislava, Slovakia
,
Min Hu
6   Guangzhou Sport University, Guangzhou Sport University, Guangzhou, China
,
Taija Juutinen Finni
7   Faculty of Sport and Health Sciences, University of Jyväskylä, Jyvaskyla, Finland
,
Lisa Umlauff
1   Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Cologne, Germany
,
Moritz Schumann
2   Department of Sports Medicine and Exercise Therapy, Chemnitz University of Technology, Chemnitz, Germany
4   Faculty of Physical Education, Shanghai Jiao Tong University, Shanghai, China
8   Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
,
Shulin Cheng
4   Faculty of Physical Education, Shanghai Jiao Tong University, Shanghai, China
7   Faculty of Sport and Health Sciences, University of Jyväskylä, Jyvaskyla, Finland
8   Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China
› Author Affiliations Funding Information Finnish Funding Agency for Technology and Innovation — 2295/31/03 40126/04
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Abstract

Pneumatic resistance training (PRT) facilitates a longer time under tension that might lead to greater changes in body composition when compared to traditional resistance training (TRT), possibly enhancing serum metabolite concentrations indicative of healthy metabolic function. To assess the impact of PRT and TRT on muscular strength, body composition, and serum metabolome, 69 men (age: 31.8±7.2 years, height: 179.7±5.4 cm, weight: 81.1±9.9 kg) were randomized into two 10-week intervention groups (PRT:n=24 and TRT:n=24) and one control group (CON:n=21). Serum metabolite concentrations were assessed before and after the training intervention by high-throughput nuclear magnetic resonance. Fat mass and lean mass were obtained by bioimpedance analysis. The training intervention resulted in an increase in lean mass for both PRT (1.85±2.69%; p=0.003) and TRT (2.72±4.53%; p=0.004), while only PRT reduced statistically significantly in body fat percentage (PRT: −5.08±10.76%; p=0.019). Only in PRT and TRT significant increases in small high-density lipoproteins (S-HDL-L) and small HDL particles (S-HDL-P) were observed. When controlling for fat and lean mass, the effects on S-HDL-L/S-HDL-P diminished. Network analysis may suggest that PRT and TRT result in an increase in network connectivity and robustness. It appears that the observed improvements are associated with changes in body composition.

Keywords

body composition - metabolites - strength training

Supplementary Material



Publication History

Received: 08 January 2024

Accepted: 10 September 2024

Accepted Manuscript online:
10 September 2024

Article published online:
07 November 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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