The First Decade of SuFEx Chemistry: Advancements in SuFEx Polymerization, Non-Canonical SuFEx Reactions, and SuFEx Radiochemistry

Min Pyeong Kim; Manoj Kumar Sahoo; Joong-Hyun Chun; Sung You Hong

doi:10.1055/a-2435-5669

Synthesis, Table of Contents

Synthesis
DOI: 10.1055/a-2435-5669

short review

SuFEx Chemistry

The First Decade of SuFEx Chemistry: Advancements in SuFEx Polymerization, Non-Canonical SuFEx Reactions, and SuFEx Radiochemistry

Min Pyeong Kim‡

^aDepartment of Chemistry, Department of Chemical Engineering, and Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea

,

Manoj Kumar Sahoo‡

^aDepartment of Chemistry, Department of Chemical Engineering, and Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea

^bCenter for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea

,

Joong-Hyun Chun∗

^cDepartment of Nuclear Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea

,

Sung You Hong ∗

^aDepartment of Chemistry, Department of Chemical Engineering, and Graduate School of Carbon Neutrality, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea

^bCenter for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea

› Author Affiliations

Abstract

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Abstract

This year marks the 10th anniversary of SuFEx chemistry, a field that has witnessed significant advancements over the past decade. These include efficient synthetic strategies toward polymerization via the SuFEx approach leading to diverse polymers, alongside the discovery of new SuFExable hubs and coupling conditions. Non-canonical reactions, such as deoxyfluorination and on-water reactions, have also emerged. Furthermore, there have been substantial strides in the radiosynthesis of [¹⁸F] SuFExable hubs. This review provides an overview of these developments, focusing on polymerization, non-canonical reaction, and radiochemistry in SuFEx chemistry.

1 Introduction

2 SuFEx Polymerization

3 Non-Canonical SuFEx Reactions

4 Fluorine-18 SuFEx Radiochemistry

5 Conclusions and Outlook

Key words

SuFEx chemistry - polymerization - polymer degradation - deoxyhalogenation - radiofluorination

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