Peptide Synthesis Using Unprotected Amino Acids

Keywords

unprotected amino acids - silacyclic dipeptide - convergent synthesis

Significance

Protecting groups for the N-terminal amino and C-terminal carboxyl groups are essential in peptide synthesis. In this work, the authors have developed peptide bond formation between unprotected amino acids using two kinds of appropriate silylating reagents.

Comment

Me₂Si(Im)₂ and TMSIM were used to achieve peptide bond formation chemoselectively between two different unprotected amino acids to give a broad range of silacyclic dipeptides. Also, silacyclic dipeptides were successfully applied to convergent long peptide synthesis.