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Synthesis 2024; 56(24): 3915-3922
DOI: 10.1055/a-2445-1338
DOI: 10.1055/a-2445-1338
paper
Concise Synthesis of Tetrasubstituted 1,6-Dihydropyridazine and Pyridazine Derivatives
We gratefully acknowledge the Natural Science Foundation of Zhejiang Province (Grant LTZ22B020002), and the Natural Science Foundation of Chongqing (cstc2020jcyj-msxmX0720) for the financial support of this work.
Abstract
A novel one-pot three-steps process has been developed, including phosphine-catalyzed Rauhut–Currier reaction of γ-alkyl allenoates, Diels–Alder reaction with di-tert-butyl azodicarboxylate, followed by deprotection of Boc group to prepare tetra-substituted 1,6-dihydropyridazines in good yields. The 1,6-dihydropyridazines were easily converted to pyridazine derivatives via oxidative aromatization by DDQ.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2445-1338.
- Supporting Information
Publication History
Received: 12 August 2024
Accepted after revision: 17 October 2024
Accepted Manuscript online:
17 October 2024
Article published online:
11 November 2024
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