Abstract
Sulfonyl fluorides and sulfamoyl fluorides, as the most significant species among sulfur(VI) fluorides, have garnered considerable attention in various fields, including organic synthesis, materials science, chemical biology, and drug discovery. Fluorosulfonyl-containing radical reagents have unique reactivity and exhibit notable advantages in constructing complex organic molecules, achieving selective functional group transformations. This short review provides a detailed introduction to the diverse applications of fluorosulfonyl-containing radical reagents in organic synthesis, such as C–H bond functionalizations, difunctionalization of olefins, and tandem reactions, highlighting their crucial roles in synthesizing complex organic molecules
1 Introduction
2 Sulfuryl Chlorofluoride (FSO2Cl) as a Radical Reagent for the Synthesis of Sulfonyl Fluorides
3 FABI/IMSF as Solid-State Radical Reagents for the Synthesis of Sulfonyl Fluorides
4 Difunctionalization Reagents for the Synthesis of Bifunctional Sulfonyl Fluorides
5 Fluorosulfonamidation Reagents for the Synthesis of Sulfamoyl Fluorides
6 Conclusion
Key words
fluorosulfonyl-containing radical reagents - radical reactions - SuFEx click chemistry - fluorine chemistry - sulfonyl fluorides - sulfamoyl fluorides
