Abstract
Pd-catalyzed cross-couplings of C–H bonds have been pursued by researchers to produce
unsymmetrical C–C bonds directly for over 50 years. Such bonds are currently prepared
by Suzuki, Kumada, Stille, Neigishi, Heck, or Sonogashira coupling of C–halogen with
C–M or C–H bonds. A big challenge is to obtain high cross-selectivity of cross-coupling
products, especially when the substrates have similar chemical C–H bonds, such as
simple arenes. Lu and co-workers have studied Pd catalysis in the cross-couplings
of aryl C–H bonds since 2003. This account introduces their strategy, understanding,
and research in cross-selectivity control, C–H activation modes, and cross-coupling
establishment, and discusses the applications of the approach in synthesis.
1 Introduction
2 Cross-Selectivity Control
3 Conclusion
Key words
palladium - arene - C–H activation - cross-coupling - selectivity
