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Synthesis
DOI: 10.1055/a-2456-9530
DOI: 10.1055/a-2456-9530
feature
Nickel-Catalyzed Enantioselective Reductive Spirocyclization of 1,6-Enynes with o-Bromobenzaldehydes
This project was supported by the National Natural Science Foundation of China (22171215 and 22471203) and Hubei Provincial Outstanding Youth Fund (2022CFA092).
Abstract
We developed a Ni-catalyzed asymmetric reductive spirocyclization of 1,6-enynes with o-haloaryl aldehydes. This approach provides an efficient method for the construction of chiral spiroindanone pyrrolidine derivatives in good yields with excellent enantio- and diastereoselectivity (up to 99% ee, >20:1 dr). This reaction does not require pre-prepared organometallic reagents and exhibits excellent substrate compatibility.
Key words
nickel catalysis - enantioselectivity - reductive spirocyclization - 1,6-enynes - spiroindanonesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2456-9530.
- Supporting Information
Publication History
Received: 07 September 2024
Accepted after revision: 29 October 2024
Accepted Manuscript online:
29 October 2024
Article published online:
21 November 2024
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For selected reviews of nickel-catalyzed reductive cross-coupling reactions, see: