Synergistic Pd/Cu-Catalyzed Asymmetric Csp3–Csp3 Coupling of 1,3-Dienes with 2-Acylimidazoles
Mingze Wang
a
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. of China
,
Weiwei Zi∗
a
State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, P. R. of China
b
Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300071, P. R. of China
› Author AffiliationsWe gratefully acknowledge the National Key Research and Development Program of China (2022YFA1503700), the National Natural Science Foundation of China (22071118, 22271162, and 22188101), the Natural Science Foundation of Tianjin Municipality (21JCZDJC00350), and the Haihe Laboratory of Sustainable Chemical Transformations and Frontiers Science Center for New Organic Matter, Nankai University for financial support.
The catalytic asymmetric coupling of 1,3-dienes with carbon nucleophiles is an important process for forming Csp3–Csp3 bonds. Here, we describe a synergistic Pd/Cu-catalyzed coupling of 1,3-dienes with 2-acylimidazoles. This reaction produces 2-acylimidazole derivatives that have α,β-adjacent stereocenters in moderate yields with good to excellent stereoselectivity.
38 CCDC 2356293 [(2S,3R)-3af] contains the supplementary crystallographic data for this paper. The data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/structures
