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Semin Liver Dis
DOI: 10.1055/a-2490-1921
Review Article

LncRNAs, RNA Therapeutics, and Emerging Technologies in Liver Pathobiology

Abid A. Anwar
1   Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota
2   Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota
,
Nidhi Jalan-Sakrikar
1   Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota
2   Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota
3   Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, Minnesota
,
Robert C. Huebert
1   Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota
2   Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota
3   Mayo Clinic Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, Minnesota
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Abstract

The field of ribonucleic acid (RNA) biology has revealed an array of noncoding RNA species, particularly long noncoding RNAs (lncRNAs), which play crucial roles in liver disease pathogenesis. This review explores the diverse functions of lncRNAs in liver pathology, including metabolic-associated steatotic liver disease, hepatocellular carcinoma, alcohol-related liver disease, and cholangiopathies such as primary sclerosing cholangitis and cholangiocarcinoma. We highlight key lncRNAs that regulate lipid metabolism, inflammation, fibrosis, and oncogenesis in the liver, demonstrating their diagnostic and therapeutic potential. Emerging RNA-based therapies, such as mRNA therapy, RNA interference, and antisense oligonucleotides, offer approaches to modulate lncRNA activity and address liver disease at a molecular level. Advances in sequencing technologies and bioinformatics pipelines are simultaneously enabling the identification and functional characterization of novel lncRNAs, driving innovation in personalized medicine. In conclusion, this review highlights the potential of lncRNAs as biomarkers and therapeutic targets in liver disease and emphasizes the need for further research into their regulatory mechanisms and clinical applications.

Keywords

lncRNA - liver disease - hepatocyte - cholangiocyte


Publication History

Accepted Manuscript online:
27 November 2024

Article published online:
19 December 2024

© 2024. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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