Direct Access to 5,6-Dihydropyrido[2′,1′:2,3]pyrido-Fused Imidazo [4,5-c]quinolines via Consecutive C–N and C–C Bond Formation in Deep Eutectic Solvent under Microwave Irradiation

Upala Dasmahapatra; Badruzzaman Choudhury; Md Gulzar Ahmad; Barnali Maiti; Kaushik Chanda

doi:10.1055/a-2499-2469

Synthesis, Inhaltsverzeichnis

Synthesis 2025; 57(05): 1007-1014
DOI: 10.1055/a-2499-2469

paper

Direct Access to 5,6-Dihydropyrido[2′,1′:2,3]pyrido-Fused Imidazo [4,5-c]quinolines via Consecutive C–N and C–C Bond Formation in Deep Eutectic Solvent under Microwave Irradiation

Upala Dasmahapatra

^aDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India

,

Badruzzaman Choudhury

^aDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India

,

Md Gulzar Ahmad

^aDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India

,

Barnali Maiti∗

^aDepartment of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore-632014, India

,

Kaushik Chanda ∗

^bDepartment of Chemistry, Rabindranath Tagore University, Hojai, Assam-782435, India

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Abstract

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Abstract

Deep eutectic solvents (DESs) are a novel class of ionic liquids that have recently gained considerable attention as a sustainable, nontoxic substitute for traditional organic solvents; recent years have seen an increasing demand for DES systems to synthesize various heterocyclic moieties. Polyheterocycle-containing scaffolds are important as potential therapeutic agents. Herein, we reported a tandem methodology for the synthesis of rarely explored 5,6-dihydropyrido[2′,1′:2,3]imidazo[4,5-c]quinolines and pyrido[2′,1′:2,3]imidazo[4,5-c]quinolines in a choline chloride based DES medium under microwave irradiation. This sustainable approach offers a clean, straightforward synthetic strategy under mild reaction conditions for the synthesis of a wide range these compounds in excellent yields.

Key words

deep eutectic solvent - polyheterocycles - tandem - microwave irradiation

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Referenzen

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