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J Knee Surg
DOI: 10.1055/a-2506-2675
Original Article

A Bedside-to-Bench-to-Bedside Journey to Advance Osteochondral Allograft Transplantation towards Biologic Joint Restoration

James L. Cook 
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
James P. Stannard 
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Aaron M. Stoker 
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Kylee Rucinski 
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Brett D. Crist
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Cristi R. Cook
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Cory Crecelius
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Chantelle C. Bozynski
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Keiichi Kuroki
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
3   Department of Veterinary Pathology, University of Missouri, Columbia, Missouri
,
Lisa A. Royse 
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Renee Stucky
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Clark T. Hung
4   Department of Biomedical Engineering, Columbia University, New York, New York
,
Matthew J. Smith
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Kyle M. Schweser
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Clayton W. Nuelle
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
,
Steven DeFroda
1   Thompson Laboratory for Regenerative Orthopaedics, University of Missouri, Columbia, Missouri
2   Department of Orthopaedic Surgery, University of Missouri, Columbia, Missouri
› Author Affiliations Funding We are grateful for the funding sources that contributed to this research, including the National Institutes of Health-National Institute of Arthritis and Musculoskeletal and Skin Diseases, Department of Defense U.S. Army Medical Research Congressionally Directed Medical Research Programs, Musculoskeletal Transplant Foundation-MTF Biologics, and Patient-Centered Outcomes Research Institute; The Allen, Gordon, Littlejohn, Reeves and Thompson Family Endowments; and the Mizzou Orthopaedic Innovation Fund.
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Abstract

More than 70 million adults in the United States are impacted by osteoarthritis (OA). Symptomatic articular cartilage loss that progresses to debilitating OA is being diagnosed more frequently and earlier in life, such that a growing number of active patients are faced with life-altering health care decisions at increasingly younger ages. Joint replacement surgeries, in the form of various artificial arthroplasties, are reliable operations, especially for older (≥65 years), more sedentary patients with end-stage OA, but have major limitations for younger, more active patients. For younger adults and those who wish to remain highly active, artificial arthroplasties are associated with significantly higher levels of pain, complications, morbidity, dysfunction, and likelihood of revision. Unfortunately, non-surgical management strategies and surgical treatment options other than joint replacement are often not indicated and have not proven to be consistently successful for this large and growing population of patients. As such, these patients are often relegated to postpone surgery, take medications including opioids, profoundly alter their lifestyle, and live with pain and disability until artificial arthroplasty is more likely to meet their functional demands without high risk for early revision. As such, our research team set out to develop, test, and validate biologic joint restoration strategies that could provide consistently successful options for young and active patients with joint disorders who were not considered ideal candidates for artificial arthroplasty. In pursuit of this goal, we implemented a targeted bedside-to-bench-to-bedside translational approach to hypothesis-driven studies designed to address this major unmet need in orthopaedics by identifying and overcoming key clinical limitations and obstacles faced by health care teams and patients in realizing optimal outcomes after biologic joint restoration. The objective of this article is to condense more than two decades of rigorous patient-centered research aimed at optimizing osteochondral and meniscus allograft transplantation toward more consistently successful management of complex joint problems in young and active patients.

Keywords

knee - transplantation - osteoarthritis - osteochondral allograft - meniscus allograft


Publication History

Received: 05 December 2024

Accepted: 18 December 2024

Accepted Manuscript online:
19 December 2024

Article published online:
20 January 2025

© 2025. Thieme. All rights reserved.

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333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Hunter W. Of the structure and diseases of articulating cartilage. Philos Trans R Soc Lond 1743; 42: 514-521
    PubMedSearch in Google Scholar
  • 2 Hootman JM, Helmick CG, Barbour KE, Theis KA, Boring MA. Updated projected prevalence of self-reported doctor-diagnosed arthritis and arthritis-attributable activity limitation among US adults, 2015–2040. Arthritis Rheumatol 2016; 68 (07) 1582-1587
    CrossrefPubMedSearch in Google Scholar
  • 3 Leifer VP, Katz JN, Losina E. The burden of OA-health services and economics. Osteoarthritis Cartilage 2022; 30 (01) 10-16
    CrossrefPubMedSearch in Google Scholar
  • 4 Khan M, Adili A, Winemaker M, Bhandari M. Management of osteoarthritis of the knee in younger patients. CMAJ 2018; 190 (03) E72-E79
    CrossrefPubMedSearch in Google Scholar
  • 5 Kurtz SM, Lau E, Ong K, Zhao K, Kelly M, Bozic KJ. Future young patient demand for primary and revision joint replacement: national projections from 2010 to 2030. Clin Orthop Relat Res 2009; 467 (10) 2606-2612
    CrossrefPubMedSearch in Google Scholar
  • 6 Williams J, Albuquerque Ii JB, Nuelle CW, Stannard JP, Cook JL. Impacts of knee arthroplasty on activity level and knee function in young patients: a systematic review. J Knee Surg 2024; 37 (06) 452-459
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Nilsdotter AK, Toksvig-Larsen S, Roos EM. Knee arthroplasty: are patients' expectations fulfilled? A prospective study of pain and function in 102 patients with 5-year follow-up. Acta Orthop 2009; 80 (01) 55-61
    CrossrefPubMedSearch in Google Scholar
  • 8 Witjes S, van Geenen RCI, Koenraadt KLM. et al. Expectations of younger patients concerning activities after knee arthroplasty: are we asking the right questions?. Qual Life Res 2017; 26 (02) 403-417
    CrossrefPubMedSearch in Google Scholar
  • 9 Bayliss LE, Culliford D, Monk AP. et al. The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study. Lancet 2017; 389 (10077): 1424-1430
    CrossrefPubMedSearch in Google Scholar
  • 10 Santaguida PL, Hawker GA, Hudak PL. et al. Patient characteristics affecting the prognosis of total hip and knee joint arthroplasty: a systematic review. Can J Surg 2008; 51 (06) 428-436
    PubMedSearch in Google Scholar
  • 11 Walker-Santiago R, Tegethoff JD, Ralston WM, Keeney JA. Revision total knee arthroplasty in young patients: Higher early reoperation and rerevision. J Arthroplasty 2021; 36 (02) 653-656
    CrossrefPubMedSearch in Google Scholar
  • 12 Arnold MP, Hirschmann MT, Verdonk PCM. See the whole picture: knee preserving therapy needs more than surface repair. Knee Surg Sports Traumatol Arthrosc 2012; 20 (02) 195-196
    CrossrefPubMedSearch in Google Scholar
  • 13 Zhao R, Carlson AM, Ilfeld BM. et al. Patient factors in the decision to delay total knee arthroplasty. Value Health 2015; 18 (03) A48
    CrossrefPubMedSearch in Google Scholar
  • 14 Mather III RC, Hug KT, Orlando LA. et al. Economic evaluation of access to musculoskeletal care: the case of waiting for total knee arthroplasty. BMC Musculoskelet Disord 2014; 15: 22
    CrossrefPubMedSearch in Google Scholar
  • 15 Bugbee WD, Pallante-Kichura AL, Görtz S, Amiel D, Sah R. Osteochondral allograft transplantation in cartilage repair: graft storage paradigm, translational models, and clinical applications. J Orthop Res 2016; 34 (01) 31-38
    CrossrefPubMedSearch in Google Scholar
  • 16 Sherman SL, Garrity J, Bauer K, Cook J, Stannard J, Bugbee W. Fresh osteochondral allograft transplantation for the knee: current concepts. J Am Acad Orthop Surg 2014; 22 (02) 121-133
    PubMedSearch in Google Scholar
  • 17 Beaver RJ, Mahomed M, Backstein D, Davis A, Zukor DJ, Gross AE. Fresh osteochondral allografts for post-traumatic defects in the knee. A survivorship analysis. J Bone Joint Surg Br 1992; 74 (01) 105-110
    CrossrefPubMedSearch in Google Scholar
  • 18 Familiari F, Cinque ME, Chahla J. et al. Clinical outcomes and failure rates of osteochondral allograft transplantation in the knee: a systematic review. Am J Sports Med 2018; 46 (14) 3541-3549
    CrossrefPubMedSearch in Google Scholar
  • 19 Kunze KN, Ramkumar PN, Manzi JE, Wright-Chisem J, Nwachukwu BU, Williams III RJ. Risk factors for failure after osteochondral allograft transplantation of the knee: a systematic review and exploratory meta-analysis. Am J Sports Med 2023; 51 (05) 1356-1367
    CrossrefPubMedSearch in Google Scholar
  • 20 Schreiner AJ, Stoker AM, Bozynski CC, Kuroki K, Stannard JP, Cook JL. Clinical application of the basic science of articular cartilage pathology and treatment. J Knee Surg 2020; 33 (11) 1056-1068
    Thieme ConnectPubMedSearch in Google Scholar
  • 21 Oladeji LO, Cook JL. Cooled radiofrequency ablation for the treatment of osteoarthritis-related knee pain: evidence, indications, and outcomes. J Knee Surg 2019; 32 (01) 65-71
    Thieme ConnectPubMedSearch in Google Scholar
  • 22 Peng H, Ou A, Huang X. et al. Osteotomy around the knee: the surgical treatment of osteoarthritis. Orthop Surg 2021; 13 (05) 1465-1473
    CrossrefPubMedSearch in Google Scholar
  • 23 Rivera JC, Beachler JA. Distraction arthroplasty compared to other cartilage preservation procedures in patients with post-traumatic arthritis: a systematic review. Strateg Trauma Limb Reconstr 2018; 13 (02) 61-67
    CrossrefPubMedSearch in Google Scholar
  • 24 Rucinski K, Cook JL. Effects of preoperative opioid education on postoperative opioid use and pain management in orthopaedics: a systematic review. J Orthop 2020; 20: 154-159
    CrossrefPubMedSearch in Google Scholar
  • 25 Cook JL, Stannard JP. Current use of biologics in clinical orthopaedics. Green County Medical Society J 2018; 77: 14-17
    PubMedSearch in Google Scholar
  • 26 Gunaratne R, Pratt DN, Banda J, Fick DP, Khan RJK, Robertson BW. Patient dissatisfaction following total knee arthroplasty: a systematic review of the literature. J Arthroplasty 2017; 32 (12) 3854-3860
    CrossrefPubMedSearch in Google Scholar
  • 27 Kim TK, Chang CB, Kang YG, Kim SJ, Seong SC. Causes and predictors of patient's dissatisfaction after uncomplicated total knee arthroplasty. J Arthroplasty 2009; 24 (02) 263-271
    CrossrefPubMedSearch in Google Scholar
  • 28 Nakano N, Shoman H, Olavarria F, Matsumoto T, Kuroda R, Khanduja V. Why are patients dissatisfied following a total knee replacement? A systematic review. Int Orthop 2020; 44 (10) 1971-2007
    CrossrefPubMedSearch in Google Scholar
  • 29 Crimmins EM. Lifespan and healthspan: past, present, and promise. Gerontologist 2015; 55 (06) 901-911
    CrossrefPubMedSearch in Google Scholar
  • 30 Langhammer B, Bergland A, Rydwik E. The importance of physical activity exercise among older people. BioMed Res Int 2018; 2018: 7856823
    CrossrefPubMedSearch in Google Scholar
  • 31 Ng KW, Lima EG, Bian L. et al. Passaged adult chondrocytes can form engineered cartilage with functional mechanical properties: a canine model. Tissue Eng Part A 2010; 16 (03) 1041-1051
    CrossrefPubMedSearch in Google Scholar
  • 32 Bian L, Stoker AM, Marberry KM, Ateshian GA, Cook JL, Hung CT. Effects of dexamethasone on the functional properties of cartilage explants during long-term culture. Am J Sports Med 2010; 38 (01) 78-85
    CrossrefPubMedSearch in Google Scholar
  • 33 O'Connell GD, Lima EG, Bian L. et al. Toward engineering a biological joint replacement. J Knee Surg 2012; 25 (03) 187-196
    Thieme ConnectPubMedSearch in Google Scholar
  • 34 Stoker A, Garrity JT, Hung CT, Stannard JP, Cook J. Improved preservation of fresh osteochondral allografts for clinical use. J Knee Surg 2012; 25 (02) 117-125
    Thieme ConnectPubMedSearch in Google Scholar
  • 35 Garrity JT, Stoker AM, Sims HJ, Cook JL. Improved osteochondral allograft preservation using serum-free media at body temperature. Am J Sports Med 2012; 40 (11) 2542-2548
    CrossrefPubMedSearch in Google Scholar
  • 36 Cook JL, Stoker AM, Stannard JP. et al. A novel system improves preservation of osteochondral allografts. Clin Orthop Relat Res 2014; 472 (11) 3404-3414
    CrossrefPubMedSearch in Google Scholar
  • 37 Cook JL, Stannard JP, Stoker AM. et al. Importance of donor chondrocyte viability for osteochondral allografts. Am J Sports Med 2016; 44 (05) 1260-1268
    CrossrefPubMedSearch in Google Scholar
  • 38 Nover AB, Stefani RM, Lee SL. et al. Long-term storage and preservation of tissue engineered articular cartilage. J Orthop Res 2016; 34 (01) 141-148
    CrossrefPubMedSearch in Google Scholar
  • 39 Nuelle CW, Nuelle JA, Cook JL, Stannard JP. Patient factors, donor age and graft storage duration affect osteochondral allograft outcomes in knees with or without comorbidities. J Knee Surg 2017; 30 (02) 179-184
    Thieme ConnectPubMedSearch in Google Scholar
  • 40 Crist BD, Stoker AM, Pfeiffer FM. et al. Optimising femoral-head osteochondral allograft transplantation in a preclinical model. J Orthop Translat 2015; 5: 48-56
    CrossrefPubMedSearch in Google Scholar
  • 41 Oladeji LO, Cook JL, Stannard JP, Crist BD. Large fresh osteochondral allografts for the hip: growing the evidence. Hip Int 2018; 28 (03) 284-290
    CrossrefPubMedSearch in Google Scholar
  • 42 Oladeji LO, Stannard JP, Cook CR. et al. Effects of autogenous bone marrow aspirate concentrate on radiographic integration of femoral condylar osteochondral allografts. Am J Sports Med 2017; 45 (12) 2797-2803
    CrossrefPubMedSearch in Google Scholar
  • 43 Stoker AM, Stannard JP, Kuroki K, Bozynski CC, Pfeiffer FM, Cook JL. Validation of the Missouri Osteochondral Allograft Preservation System for the maintenance of osteochondral allograft quality during prolonged storage. Am J Sports Med 2018; 46 (01) 58-65
    CrossrefPubMedSearch in Google Scholar
  • 44 Stoker AM, Stannard JP, Cook JL. Chondrocyte viability at time of transplantation for osteochondral allografts preserved by the Missouri Osteochondral Preservation System versus standard tissue bank protocol. J Knee Surg 2018; 31 (08) 772-780
    Thieme ConnectPubMedSearch in Google Scholar
  • 45 Stoker AM, Baumann CA, Stannard JP, Cook JL. Bone marrow aspirate concentrate versus platelet rich plasma to enhance osseous integration potential for osteochondral allografts. J Knee Surg 2018; 31 (04) 314-320
    Thieme ConnectPubMedSearch in Google Scholar
  • 46 Baumann CA, Baumann JR, Bozynski CC, Stoker AM, Stannard JP, Cook JL. Comparison of techniques for preimplantation treatment of osteochondral allograft bone. J Knee Surg 2019; 32 (01) 97-104
    Thieme ConnectPubMedSearch in Google Scholar
  • 47 Stoker AM, Caldwell KM, Stannard JP, Cook JL. Metabolic responses of osteochondral allografts to re-warming. J Orthop Res 2019; 37 (07) 1530-1536
    CrossrefPubMedSearch in Google Scholar
  • 48 Rucinski K, Cook JL, Crecelius CR, Stucky R, Stannard JP. Effects of compliance with procedure-specific postoperative rehabilitation protocols on initial outcomes after osteochondral and meniscal allograft transplantation in the knee. Orthop J Sports Med 2019; 7 (11) 23 25967119884291
    CrossrefPubMedSearch in Google Scholar
  • 49 Oladeji LO, Dreger TK, Pratte EL. et al. Total knee arthroplasty versus osteochondral allograft: prevalence and risk factors following tibial plateau fractures. J Knee Surg 2019; 32 (04) 380-386
    Thieme ConnectPubMedSearch in Google Scholar
  • 50 Leary E, Stoker AM, Cook JL. Classification, categorization, and algorithms for articular cartilage defects. J Knee Surg 2020; 33 (11) 1069-1077
    Thieme ConnectPubMedSearch in Google Scholar
  • 51 Hayden R, Rucinski K, Crecelius CR, Stucky R, Stannard JP, Cook JL. Outcomes associated with behavioral evaluation and counseling for patients undergoing orthopaedic surgery - a systematic review. J Orthop 2020; 21: 178-182
    CrossrefPubMedSearch in Google Scholar
  • 52 Thomas DM, Stannard JP, Pfeiffer FM, Cook JL. Biomechanical properties of bioabsorbable fixation for osteochondral shell allografts. J Knee Surg 2020; 33 (04) 365-371
    Thieme ConnectPubMedSearch in Google Scholar
  • 53 Stannard JP, Cook JL. Prospective assessment of outcomes after primary unipolar, multisurface, and bipolar osteochondral allograft transplantations in the knee: a comparison of 2 preservation methods. Am J Sports Med 2020; 48 (06) 1356-1364
    CrossrefPubMedSearch in Google Scholar
  • 54 Schreiner AJ, Stannard JP, Cook CR. et al. Initial clinical outcomes comparing frozen versus fresh meniscus allograft transplants. Knee 2020; 27 (06) 1811-1820
    CrossrefPubMedSearch in Google Scholar
  • 55 Brusalis CM, Greditzer IV HG, Fabricant PD, Stannard JP, Cook JL. BioCartilage augmentation of marrow stimulation procedures for cartilage defects of the knee: two-year clinical outcomes. Knee 2020; 27 (05) 1418-1425
    CrossrefPubMedSearch in Google Scholar
  • 56 Stannard JP, Stannard JT, Schreiner AJ. Fresh osteochondral allograft transplants in the knee: bipolar and beyond. J Knee Surg 2020; 33 (12) 1172-1179
    Thieme ConnectPubMedSearch in Google Scholar
  • 57 Smith PA, Humpherys JL, Stannard JP, Cook JL. Impact of medial meniscotibial ligament disruption compared to peripheral medial meniscal tear on knee biomechanics. J Knee Surg 2021; 34 (07) 784-792
    Thieme ConnectPubMedSearch in Google Scholar
  • 58 Zitsch BP, Stannard JP, Worley JR, Cook JL, Leary EV. Patient-reported outcomes for large bipolar osteochondral allograft transplantation in combination with realignment osteotomies for the knee. J Knee Surg 2021; 34 (11) 1260-1266
    Thieme ConnectPubMedSearch in Google Scholar
  • 59 Schreiner AJ, Stannard JP, Cook CR. et al. Comparison of meniscal allograft transplantation techniques using a preclinical canine model. J Orthop Res 2021; 39 (01) 154-164
    CrossrefPubMedSearch in Google Scholar
  • 60 Schreiner AJ, Stannard JP, Stoker AM. et al. Unicompartmental bipolar osteochondral and meniscal allograft transplantation is effective for treatment of medial compartment gonarthrosis in a canine model. J Orthop Res 2021; 39 (05) 1093-1102
    CrossrefPubMedSearch in Google Scholar
  • 61 Crecelius CR, Van Landuyt KJ, Schaal R. Postoperative management for articular cartilage surgery in the knee. J Knee Surg 2021; 34 (01) 20-29
    Thieme ConnectPubMedSearch in Google Scholar
  • 62 De Armond CC, Kim SE, Lewis DD. et al. Three-dimensional-printed custom guides for bipolar coxofemoral osteochondral allograft in dogs. PLoS One 2021; 16 (02) e0244208
    CrossrefPubMedSearch in Google Scholar
  • 63 Franklin SP, Stoker AM, Murphy SM. et al. Outcomes associated with osteochondral allograft transplantation in dogs. Front Vet Sci 2021; 8: 759610
    CrossrefPubMedSearch in Google Scholar
  • 64 Smith CJ, Crist BD, Rucinski K. et al. Comparisons of initial outcomes and cost-effectiveness after total ankle arthroplasty versus bipolar osteochondral allograft transplantation in the ankle: a retrospective cohort study. Curr Orthop Pract 2021; 32: 232-236
    CrossrefPubMedSearch in Google Scholar
  • 65 Cook JL, Rucinski K, Crecelius CR, Ma R, Stannard JP. Return to sport after large single-surface, multisurface, or bipolar osteochondral allograft transplantation in the knee using shell grafts. Orthop J Sports Med 2021; 9 (01) 23 25967120967928
    CrossrefPubMedSearch in Google Scholar
  • 66 Luk J, Stoker AM, Teixeiro E. et al. Systematic review of osteochondral allograft transplant immunology: how can we further optimize outcomes. J Knee Surg 2021; 34 (01) 30-38
    Thieme ConnectPubMedSearch in Google Scholar
  • 67 Rucinski K, Stannard JP, Crecelius C, Cook JL. Changes in knee range of motion after large osteochondral allograft transplantations. Knee 2021; 28: 207-213
    CrossrefPubMedSearch in Google Scholar
  • 68 Liu J, Crist BD, Stoker AM, Stannard JP, Cook JL. Reamer-irrigator-aspirate versus bone marrow aspirate concentrate for osteoprogenitor cell retention and osteoinductive protein release on cancellous bone. J Orthop 2021; 27: 13-16
    CrossrefPubMedSearch in Google Scholar
  • 69 Rucinski K, Stannard JP, Cook JL. Incidence and costs of surgical site infection after osteochondral allograft transplant surgery in the knee. Orthop J Sports Med 2022; 10 (03) 23 259671221084701
    CrossrefPubMedSearch in Google Scholar
  • 70 Cook JL, Rucinski K, Crecelius C, Fenkell B, Stannard JP. Assessment of outcomes after multisurface osteochondral allograft transplantations in the knee. Orthop J Sports Med 2022; 10 (06) 23 259671221102452
    CrossrefPubMedSearch in Google Scholar
  • 71 Buyuk AF, Stannard JP, Rucinski K. et al. The Missouri Osteochondral Preservation System is associated with better short-term outcomes than standard preservation when performing osteochondral allograft transplantation using shell grafts for patellofemoral lesions. Arthroscopy 2023; 39 (03) 650-659
    CrossrefPubMedSearch in Google Scholar
  • 72 Rodriguez A, Baumann J, Bezold W. et al. Functional biomechanical comparison of Latarjet vs. distal tibial osteochondral allograft for anterior glenoid defect reconstruction. J Shoulder Elbow Surg 2023; 32 (02) 374-382
    CrossrefPubMedSearch in Google Scholar
  • 73 DeFroda SF, Hanish S, Muhammad M, Cook JL, Crist B. Graft options for hip labral reconstruction. JBJS Rev 2022; 10 (12) e22
    CrossrefPubMedSearch in Google Scholar
  • 74 Ewing MA, Stoker AM, Leary EV. et al. Treatment monitoring capabilities of serum and urine biomarkers for meniscus allograft transplantation in a preclinical canine model. Am J Sports Med 2022; 50 (10) 2714-2721
    CrossrefPubMedSearch in Google Scholar
  • 75 Petersen CA, Spack KA, Cook JL, Hung CT, Rosenwasser MP, Ateshian GA. Bendable osteochondral allografts for patellar resurfacing: a finite element analysis of congruence. J Biomech 2022; 142: 111240
    CrossrefPubMedSearch in Google Scholar
  • 76 Stoker AM, Leary EV, Rucinski K. et al. Serum and urine biomarkers for predicting outcomes after osteochondral allograft transplantation surgery. Paper presented at: Orthopaedic Research Society Annual Meeting;. February 4–8, 2022 ; Tampa, FL
    PubMedSearch in Google Scholar
  • 77 Paul KD, Patel RK, Arguello AM. et al. Variability in the processing of fresh osteochondral allografts. J Knee Surg 2023; 36 (04) 450-455
    Thieme ConnectPubMedSearch in Google Scholar
  • 78 Wissman R, Cook C, Cook JL, Okoye M, Rucisnki K, Stannard JP. Initial validation of a modified MRI scoring system for assessing outcomes after single-surface osteochondral shell allograft transplantation in the knee. J Knee Surg 2023; 36 (05) 548-554
    Thieme ConnectPubMedSearch in Google Scholar
  • 79 Rucinski K, Stucky R, Crecelius CR, Stannard JP, Cook JL. Effects of patient assessment and education by an integrated care team on postoperative adherence and failure rates after osteochondral allograft and meniscal allograft transplantation in the knee. Orthop J Sports Med 2023; 11 (05) 23 259671231160780
    CrossrefPubMedSearch in Google Scholar
  • 80 Rucinski K, Cook JL, Royse LA. The complexity of patient adherence in orthopaedics: a qualitative study to identify barriers and develop strategies for adherence partnerships. Musculoskeletal Care 2023; 21 (04) 1387-1400
    CrossrefPubMedSearch in Google Scholar
  • 81 Royse LA, Strother S, Trachsel M, Mehr DR, Hoffman K, Cook JL. Engaging patients and caregivers to develop a patient-centered agenda for comparative effectiveness research focused on the treatment of complex knee problems. J Knee Surg 2023; 36 (14) 1422-1437
    Thieme ConnectPubMedSearch in Google Scholar
  • 82 Kelly SR, Stannard JT, Reddy J, Cook JL, Stannard JP, Nuelle CW. Meniscus allograft transplantation with bone plugs using knotless all-suture anchors and cortical button suspensory fixation. Arthrosc Tech 2023; 12 (10) e1707-e1714
    CrossrefPubMedSearch in Google Scholar
  • 83 Rucinski K, Crecelius CR, Stucky R, Stannard JP, Cook JL. Integrated care for comprehensive management of patients with osteoarthritis: program development and implementation. J Knee Surg 2023; 36 (14) 1392-1398
    Thieme ConnectPubMedSearch in Google Scholar
  • 84 Gieg SD, Stannard JP, Cook JL. Evaluating the role and impact of health literacy for patients undergoing knee surgery. J Knee Surg 2023; 36 (14) 1399-1404
    Thieme ConnectPubMedSearch in Google Scholar
  • 85 Rucinski K, Njai A, Stucky R, Crecelius CR, Cook JL. Patient adherence following knee surgery: evidence-based practices to equip patients for success. J Knee Surg 2023; 36 (14) 1405-1412
    Thieme ConnectPubMedSearch in Google Scholar
  • 86 DeFroda SF, Crist B, Cook JL. Arthroscopic hip labral reconstruction with fresh meniscal allograft. Arthrosc Tech 2023; 12 (06) e813-e821
    CrossrefPubMedSearch in Google Scholar
  • 87 Wolfe PN, Stoker AM, Crist BD, Leary E, Bozynski CC, Cook JL. Evaluation of mechanistic serum and urine biomarkers for secondary osteoarthritis associated with developmental dysplasia of the hip. J Orthop 2023; 42: 24-29
    CrossrefPubMedSearch in Google Scholar
  • 88 Wolfe PN, Stoker AM, Leary E, Crist BD, Bozynski CC, Cook JL. Evaluation of serum and urine biomarker panels for developmental dysplasia of the hip prior to onset of secondary osteoarthritis. Cartilage 2024; 15 (02) 164-174
    CrossrefPubMedSearch in Google Scholar
  • 89 Rucinski K, Crecelius CR, Cook JL. Patient and healthcare team adherence in orthopaedics: a systematic review to initiate optimized definitions, metrics, and implementation strategies. J Pat Care 2022; 8: 203
    PubMedSearch in Google Scholar
  • 90 Luk J, Troyer L, Guess TM, Teixeiro E, Stannard JP, Cook JL. Characterizing osteochondral allograft biomechanics for optimizing transplant success: a systematic review. J Knee Surg 2024; 37 (03) 227-237
    Thieme ConnectPubMedSearch in Google Scholar
  • 91 Cook JL, Cook CR, Rucinski K, Stannard JP. Serial ultrasonographic imaging can predict failure after meniscus allograft transplantation. Ultrasound 2023; 31 (02) 139-146
    CrossrefPubMedSearch in Google Scholar
  • 92 Cook JL, Rucinski K, Crecelius CR, Kfuri M, Stannard JP. Treatment failures (revision or arthroplasty) after knee osteochondral allograft transplantation with minimum two-year follow-up. Knee 2024; 46: 128-135
    CrossrefPubMedSearch in Google Scholar
  • 93 Cook JL, Rucinski K, Crecelius CR, Stannard JP. Initial outcomes after unicompartmental tibiofemoral bipolar osteochondral and meniscal allograft transplantation in the knee using MOPS-preserved fresh (viable) tissues. Am J Sports Med 2023; 51 (03) 596-604
    CrossrefPubMedSearch in Google Scholar
  • 94 Rucinski K, Cook JL, Schweser KM, Crist BD. Short-term outcomes after bipolar osteochondral allograft transplantation (OCAT) in the ankle. J Foot Ankle Surg 2024; 63 (02) 207-213
    CrossrefPubMedSearch in Google Scholar
  • 95 Oladeji LO, Albracht BG, Keeney JA. Conversion total knee arthroplasty after failed osteochondral allograft reconstruction: similar functional performance with lower patient satisfaction. J Arthroplasty 2023; 38 (06) 1045-1051
    CrossrefPubMedSearch in Google Scholar
  • 96 Luk J, Bozynski CC, Williams J. et al. Cell-mediated immune responses may play roles in osteochondral allograft transplantation osteointegration failures. J Knee Surg 2024; 37 (11) 812-819
    Thieme ConnectPubMedSearch in Google Scholar
  • 97 Lam K, Bozynski CC, Cook CR. et al. Comparison of reamer irrigator aspirator (RIA) suspension versus bone marrow aspirate concentrate (BMC) for percutaneous treatment of long bone nonunions-a preclinical canine model. Injury 2024; 55 (06) 111590
    CrossrefPubMedSearch in Google Scholar
  • 98 Cook JL, Rucinski K, Wissman R, Crecelius C, DeFroda S, Crist BD. Outcomes following open acetabular labrum reconstruction: comparing fresh-frozen tendon with fresh meniscus allograft transplantation. J Orthop 2024; 53: 13-19
    CrossrefPubMedSearch in Google Scholar
  • 99 Nuelle CW, Rucinski K, Stannard JP, Ma R, Kfuri M, Cook JL. Comparison of outcomes after primary versus salvage osteochondral allograft transplantation for femoral condyle osteochondritis dissecans lesions. Orthop J Sports Med 2024; 12 (03) 23 259671241232431
    CrossrefPubMedSearch in Google Scholar
  • 100 Rucinski K, Stannard JP, Crecelius C, Nuelle C, Cook JL. Accelerated versus standard rehabilitation after meniscus allograft transplantation in the knee. J Knee Surg 2024; 37 (10) 710-717
    Thieme ConnectPubMedSearch in Google Scholar
  • 101 Cook JL, Rucinski K, Leary EV. et al. Midterm outcomes after osteochondral allograft transplantation in the knee using high-chondrocyte-viability grafts. Am J Sports Med 2024; 52 (13) 3244-3254
    CrossrefPubMedSearch in Google Scholar
  • 102 Williams J, Rucinski K, Stucky R. et al. Enrollment in a behavioral health program positively impacts 2-year cumulative survival rates in osteochondral allograft transplant patients. J Knee Surg 2024; 38: 28-34
    PubMedSearch in Google Scholar
  • 103 Cook JL, Drager J, Bozynski CC. et al. Iron chelators augment large osteochondral allograft osseointegration in a preclinical canine model. J Orthop Trauma 2024; 38 (11S): S40-S47
    CrossrefPubMedSearch in Google Scholar
  • 104 Messier SP, Callahan LF, Losina E. et al. The osteoarthritis prevention study (TOPS) - a randomized controlled trial of diet and exercise to prevent knee osteoarthritis: design and rationale. Osteoarthr Cartil Open 2023; 6 (01) 100418
    CrossrefPubMedSearch in Google Scholar
  • 105 Lexer E. Die Verwendung der freien Knochenplastic nebst Versuchen über Gelenkversteifung und Gelenktransplatation. Langenbecks Arch Klin Chir Ver Dtsch Z Chir. 1908; 86: 939-954
    PubMedSearch in Google Scholar
  • 106 Gross AE, Shasha N, Aubin P. Long-term follow up of the use of fresh osteochondral allografts for posttraumatic knee defects. Clin Orthop Relat Res 2005; (435) 79-87
    CrossrefPubMedSearch in Google Scholar
  • 107 Meyers MH. Resurfacing of the femoral head with fresh osteochondral allografts. Long-term results. Clin Orthop Relat Res 1985; (197) 111-114
    PubMedSearch in Google Scholar
  • 108 Frank RM, Lee S, Cotter EJ, Hannon CP, Leroux T, Cole BJ. Outcomes of osteochondral allograft transplantation with and without concomitant meniscus allograft transplantation: a comparative matched group analysis. Am J Sports Med 2018; 46 (03) 573-580
    CrossrefPubMedSearch in Google Scholar
  • 109 Farr J, Gracitelli GC, Shah N, Chang EY, Gomoll AH. High failure rate of a decellularized osteochondral allograft for the treatment of cartilage lesions. Am J Sports Med 2016; 44 (08) 2015-2022
    CrossrefPubMedSearch in Google Scholar
  • 110 Langer F, Czitrom A, Pritzker KP, Gross AE. The immunogenicity of fresh and frozen allogeneic bone. J Bone Joint Surg Am 1975; 57 (02) 216-220
    CrossrefPubMedSearch in Google Scholar
  • 111 Sirlin CB, Brossmann J, Boutin RD. et al. Shell osteochondral allografts of the knee: comparison of mr imaging findings and immunologic responses. Radiology 2001; 219 (01) 35-43
    CrossrefPubMedSearch in Google Scholar
  • 112 Stevenson S, Li XQ, Martin B. The fate of cancellous and cortical bone after transplantation of fresh and frozen tissue-antigen-matched and mismatched osteochondral allografts in dogs. J Bone Joint Surg Am 1991; 73 (08) 1143-1156
    CrossrefPubMedSearch in Google Scholar
  • 113 Stevenson S, Horowitz M. The response to bone allografts. J Bone Joint Surg Am 1992; 74 (06) 939-950
    CrossrefPubMedSearch in Google Scholar
  • 114 Friedlaender GE, Horowitz MC. Immune responses to osteochondral allografts: nature and significance. Orthopedics 1992; 15 (10) 1171-1175
    CrossrefPubMedSearch in Google Scholar
  • 115 Langer F, Gross AE. Immunogenicity of allograft articular cartilage. J Bone Joint Surg Am 1974; 56 (02) 297-304
    CrossrefPubMedSearch in Google Scholar
  • 116 Langer F, Gross AE, West M, Urovitz EP. The immunogenicity of allograft knee joint transplants. Clin Orthop Relat Res 1978; (132) 155-162
    PubMedSearch in Google Scholar
  • 117 Elves MW. Immunological studies of osteoarticular allografts. Proc R Soc Med 1971; 64 (06) 644
    PubMedSearch in Google Scholar
  • 118 Elves MW. Newer knowledge of the immunology of bone and cartilage. Clin Orthop Relat Res 1976; (120) 232-259
    PubMedSearch in Google Scholar
  • 119 Phipatanakul WP, VandeVord PJ, Teitge RA, Wooley PH. Immune response in patients receiving fresh osteochondral allografts. Am J Orthop 2004; 33 (07) 345-348
    PubMedSearch in Google Scholar
  • 120 Boccaccio A, Ballini A, Pappalettere C, Tullo D, Cantore S, Desiate A. Finite element method (FEM), mechanobiology and biomimetic scaffolds in bone tissue engineering. Int J Biol Sci 2011; 7 (01) 112-132
    CrossrefPubMedSearch in Google Scholar
  • 121 Brown TD, Radin EL, Martin RB, Burr DB. Finite element studies of some juxtarticular stress changes due to localized subchondral stiffening. J Biomech 1984; 17 (01) 11-24
    CrossrefPubMedSearch in Google Scholar
  • 122 Bus MPA, van de Sande MAJ, Taminiau AHM, Dijkstra PDS. Is there still a role for osteoarticular allograft reconstruction in musculoskeletal tumour surgery? a long-term follow-up study of 38 patients and systematic review of the literature. Bone Joint J 2017; 99-B (04) 522-530
    CrossrefPubMedSearch in Google Scholar
  • 123 Meric G, Gracitelli GC, Görtz S, De Young AJ, Bugbee WD. Fresh osteochondral allograft transplantation for bipolar reciprocal osteochondral lesions of the knee. Am J Sports Med 2015; 43 (03) 709-714
    CrossrefPubMedSearch in Google Scholar
  • 124 Murray MJ, LeBlanc CH. Clinic follow-up from the emergency department: do patients show up?. Ann Emerg Med 1996; 27 (01) 56-58
    CrossrefPubMedSearch in Google Scholar
  • 125 Badge HM, Churches T, Naylor JM. et al. Non-compliance with clinical guidelines increases the risk of complications after primary total hip and knee joint replacement surgery. PLoS ONE 2021; 16 (11) e0260146
    CrossrefPubMedSearch in Google Scholar
  • 126 Campbell CM, Jamison RN, Edwards RR. Psychological screening/phenotyping as predictors for spinal cord stimulation. Curr Pain Headache Rep 2013; 17 (01) 307
    CrossrefPubMedSearch in Google Scholar
  • 127 Snyder AG. Psychological assessment of the patient undergoing bariatric surgery. Ochsner J 2009; 9 (03) 144-148
    PubMedSearch in Google Scholar
  • 128 Flores CA. Psychological assessment for bariatric surgery: current practices. Arq Bras Cir Dig 2014; 27 Suppl 1 (Suppl. 01) 59-62
    CrossrefPubMedSearch in Google Scholar
  • 129 Assenmacher AT, Pareek A, Reardon PJ, Macalena JA, Stuart MJ, Krych AJ. Long-term outcomes after osteochondral allograft: a systematic review at long-term follow-up of 12.3 years. Arthroscopy 2016; 32 (10) 2160-2168
    CrossrefPubMedSearch in Google Scholar
  • 130 Aubin PP, Cheah HK, Davis AM, Gross AE. Long-term followup of fresh femoral osteochondral allografts for posttraumatic knee defects. Clin Orthop Relat Res 2001; (391) S318-S327
    CrossrefPubMedSearch in Google Scholar
  • 131 Vannini F, Buda R, Pagliazzi G, Ruffilli A, Cavallo M, Giannini S. Osteochondral allografts in the ankle joint: state of the art. Cartilage 2013; 4 (03) 204-213
    CrossrefPubMedSearch in Google Scholar
  • 132 Horton MT, Pulido PA, McCauley JC, Bugbee WD. Revision osteochondral allograft transplantations: do they work?. Am J Sports Med 2013; 41 (11) 2507-2511
    CrossrefPubMedSearch in Google Scholar
  • 133 Steinhoff AK, Bugbee WD. Outcomes of total knee arthroplasty after osteochondral allograft transplantation. Orthop J Sports Med 2014; 2 (09) 23 25967114550276
    CrossrefPubMedSearch in Google Scholar