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Synthesis
DOI: 10.1055/a-2515-0227
DOI: 10.1055/a-2515-0227
feature
Cobalt-Catalyzed Regioselective Hydroformylation of Allylic Alcohol Esters
We are grateful for financial support from the National Key Research and Development Program of China (Grant No. 2022YFA1506100), the National Natural Science Foundation of China (Grant Nos. 22371294, 21821002, 22203034), the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB0610000), the Beijing National Laboratory for Molecular Sciences (BNLMS202304), the Shanghai Science and Technology Committee (Grant No. 20XD1425000) and the State Key Laboratory of Elemento-Organic Chemistry, Nankai University (Grant No. 202201).
Abstract
Aliphatic aldehydes are important building blocks in organic synthesis due to their high reactivity and versatility. Herein, we report a simple, mild and efficient method for the hydroformylation of allyl alcohol esters under cobalt catalysis. This procedure offers good functional group tolerance, moderate to good product yields and exclusive chemo- and regioselectivity, making it an attractive method to prepare aldehydes with linear selectivity.
Key words
hydroformylation - synthesis gas - cobalt - functionalized olefins - allyl alcohol derivativesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2515-0227.
- Supporting Information
Publication History
Received: 14 November 2024
Accepted after revision: 11 January 2025
Accepted Manuscript online:
11 January 2025
Article published online:
24 February 2025
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For reviews on hydroformylation of alkenes, see:
For selected examples of Rh-catalyzed hydroformylations, see:
For selected examples of Co-catalyzed hydroformylations, see: