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Synlett
DOI: 10.1055/a-2778-8313
Letter

The Synthesis of Amides by Photoexcited o-Nitrophenyl Benzyl Ethers and Evaluation of Biological Activity

Authors

  • Xinran Zhang

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

  • Yan Wei

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

  • Huilin Ling

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

  • Qikun Yin

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

  • Xianhe Fang

    1   School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China (Ringgold ID: RIN12682)

We are grateful for financial support from the National Natural Science Foundation of China (22301261), the Natural Science Foundation of Shandong Province (ZR2023QB012), the Science and Technology Support Program for Youth Innovation in Universities of Shandong Province (2023KJ367) and Scientific Research Foundation for Doctor of Yantai University (YX22B87).
Supported by: Science and Technology Support Program for Youth Innovation in Universities of Shandong Province 2023KJ367 Supported by: Natural Science Foundation of Shandong Province ZR2023QB012 Supported by: National Natural Science Foundation of China 22301261
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Graphical Abstract

Abstract

Herein, we have developed a method for the synthesis of amides, novel photoproducts obtained from photoexcited o-nitrophenyl benzyl ethers in metal-free conditions. Furthermore, evaluation of the biological activity revealed that compound 2s exhibits inhibitory effect on LPS-induced NO release in RAW 264.7 cells.

Keywords

Amide - Nitroarenes - Photochemistry - NO release - Hydrogen atom transfer

Supplementary Material



Publication History

Received: 03 December 2025

Accepted after revision: 23 December 2025

Accepted Manuscript online:
24 December 2025

Article published online:
23 January 2026

© 2026. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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