Thallium(III) chloride is a simple and efficient catalyst for
acylation of alcohols, phenols and thiols. It is also very effective for
geminal diacylation of aldehydes. The acylation reaction using acetic
anhydride proceeds in excellent yield in the presence of catalytic
amounts of thallium(III) chloride (1 mol%) at room temperature
within relatively short reaction times (<20 min). Structurally diverse
alcohols, phenols, thiols and aldehydes undergo acylation under
solvent-free conditions.
acylation - gem-diacylation - thallium chloride - alcohols - thiols - aldehydes
