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Synthesis 2008(23): 3846-3856
DOI: 10.1055/s-0028-1083214
DOI: 10.1055/s-0028-1083214
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Preparation of Novel Polycyclic Heterocycles Using a Tin(II) Chloride Dihydrate-Mediated Deacetalisation-Bicyclisation Sequence
Further Information
Received
12 August 2008
Publication Date:
30 October 2008 (online)
Publication History
Publication Date:
30 October 2008 (online)
Abstract
Tin(II) chloride dihydrate-mediated deacetalisation-bicyclisation procedures for the construction of novel polycyclic heterocycles from amides possessing a pendant acetal group are reported. Optimisation and scoping studies are described; using this methodology, a range of known, and novel, ring-fused heterocyclic systems have been prepared, some in enantiomerically pure form.
Key words
heterocycles - tin(II) chloride dihydrate - deacetalisation - bicyclisation - tandem processes
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