Copper(I) Iodide Catalyzed Domino
Process to Quinazolin-4(3H)-ones

Jing Zhou; Liangbing Fu; Man Lv; Jinsong Liu; Duanqing Pei; Ke Ding

doi:10.1055/s-0028-1083245

PAPER

Copper(I) Iodide Catalyzed Domino Process to Quinazolin-4(3H)-ones

Jing Zhou^a,b, Liangbing Fu^a,b,c, Man Lv^a,b, Jinsong Liu^b, Duanqing Pei^a,b, Ke Ding*^a,b
^a Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences International Business Incubator A-3, Guangzhou Science Park, Guangzhou 510663, P. R. of China
^b State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences International Business Incubator A-3, Guangzhou Science Park, Guangzhou 510663, P. R. of China
Fax: +86(20)32290485; e-Mail: ding_ke@gibh.ac.cn;
^c Graduate School of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, P. R. of China

Abstract

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Abstract

An efficient synthesis of substituted quinazolin-4(3H)-ones by a one-pot ligand-free CuI-catalyzed coupling/condensative cyclization under mild conditions is described. Our study provides an alternative strategy for the preparation of biologically active quinazolin-4(3H)-ones.

Key words

quinazolin-4(3H)-ones - one-pot - ligand-free - copper(I) iodide - coupling/condensative cyclization

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CCDC # 701749 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge at www.ccdc.cam.ac.uk/conts/retrieving.html [or from the Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB2 1EZ, UK; fax: +44(1223)336033; E-mail: deposit@ccdc.cam.ac.uk].