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Synthesis 2008(24): 3945-3950
DOI: 10.1055/s-0028-1083249
DOI: 10.1055/s-0028-1083249
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Stereoselective Formal Synthesis of Herbarumin III via Prins Cyclization
Weitere Informationen
Received
9 July 2008
Publikationsdatum:
01. Dezember 2008 (online)
Publikationsverlauf
Publikationsdatum:
01. Dezember 2008 (online)
Abstract
The total synthesis of herbarumin III is described, proving the versatility of the Prins cyclization in the synthesis of natural products. The approach is convergent and highly stereoselective. Ring-closing metathesis and alkene-rearrangement reactions are utilized as key steps in the synthesis of the macrolactone.
Key words
herbarumins - Prins cyclization - alkene rearrangement - ring-closing metathesis
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