Highly Regioselective Preparation
of 1,3-Dioxolane-4-methanol Derivatives from Glycerol Using Phosphomolybdic
Acid

Nitin Wasantrao Fadnavis; Reddipalli Gowrisankar; Gadupudi Ramakrishna; Mithilesh Kumar Mishra; Gurrala Sheelu

doi:10.1055/s-0028-1083319

PAPER

Highly Regioselective Preparation of 1,3-Dioxolane-4-methanol Derivatives from Glycerol Using Phosphomolybdic Acid

Nitin Wasantrao Fadnavis*, Reddipalli Gowrisankar, Gadupudi Ramakrishna, Mithilesh Kumar Mishra, Gurrala Sheelu
Biotransformations Laboratory, Discovery Block, Indian Institute of Chemical Technology, Uppal Road, Habsiguda, Hyderabad 500007, India
Fax: +91(40)27160512; e-Mail: fadnavis@iict.res.in; e-Mail: fadnavisnw@yahoo.com;

Abstract

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Abstract

Phosphomolybdic acid (PMA) forms a blue-colored complex with glycerol in a 1:10 molar ratio. The glycerolato complex catalyzes conversion of glycerol into 1,3-dioxolane-4-methanol derivatives with complete regiospecificity in high yields (>95%) and the catalyst can be recycled up to ten times without loss of activity or regiospecificity.

Key words

glycerol - phosphomolybdic acid - complexation - regiospecificity - 1,3-dioxolane-4-methanol

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