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Synthesis 2009(5): 809-814
DOI: 10.1055/s-0028-1083362
DOI: 10.1055/s-0028-1083362
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Versatile Selective α-Carboxylic Acid Esterification of N-Protected Amino Acids and Peptides by Alcalase
Further Information
Received
3 October 2008
Publication Date:
11 February 2009 (online)
Publication History
Publication Date:
11 February 2009 (online)
Abstract
Under continuous removal of water, the industrial protease Alcalase allows selective synthesis of α-carboxylic acid methyl, ethyl, benzyl, allyl, 2-(trimethylsilyl)ethyl, and tert-butyl esters of amino acids and peptides under mild conditions in very high yields. The purified yields range from 72% to 92%.
Key words
enzymes - amino acids - esterification - esters - protecting groups
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